Gastrointestinal Response to Injury: Canada 2007

描述（由申请人提供）：“胃肠损伤反应：加拿大2007”将是一系列会议中的第六次会议。第一次会议于1992年在科罗拉多州的铜山召开，最初的主题是“胃十二指肠粘膜防御的细胞和分子基础”，此后每三年举行一次会议。第四次和第五次会议（2001年和2004年）在加拿大魁北克省蒙特贝罗城堡举行。这些后来的会议为该计划引入了更广泛的范围，其中包括对结肠和整个小肠以及上胃肠道的胃肠道粘膜防御的调查。这种形式，以及地点，提高了该系列的成功。拟议的会议“对损伤的胃肠道反应：加拿大2007”，讨论与影响整个肠道胃肠道的疾病相关的重要和前沿主题。该计划包括三个部分，每个部分由两个单独的会议组成。第一部分探讨了调节胃肠道对损伤反应的因素，包括1)粘膜屏障和2)免疫系统。第二部分，胃肠道损伤的药物和机制涉及3)非甾体抗炎药、氧化应激和其他粘膜损伤药物，以及4)微生物-宿主相互作用。第三部分讨论了肠道损伤的表现和调节疾病结果的潜力，包括5)愈合、修复和致癌，以及6)慢性炎症及其临床后果，包括炎症性肠病。本次会议的一个主要目标是为年轻科学家提供一个独特的机会，让他们在一个开放的环境中了解胃肠道损伤反应领域的最新研究，在这个环境中，他们可以与来自世界各地的知名研究者进行正式和非正式的互动。会议还将促进在胃肠生物学不同方面工作的科学家之间以及基础和临床研究人员之间的互动。自1998年以来，会议首次有一个主要赞助商（AGA研究所），此外还有来自工业界的教育补助金，这些补助金将支持会议的费用，包括26名受邀演讲者和/或会议主席的旅行、膳食和住宿费用，这些演讲者和/或会议主席包括8名妇女、5个种族/少数民族（包括2个传统上代表性不足的少数民族）和6名初级调查人员。本申请要求提供所需资金，以支持年轻的实习调查人员出席会议的费用，否则他们可能没有机会参加这样的会议。本申请的目的是获得旅行奖励的资金，以促进年轻科学家参加“损伤的胃肠道反应：加拿大2007”。

DESCRIPTION (provided by applicant): "Gastrointestinal Response to Injury: Canada 2007" will be the sixth in a series of meetings. The first meeting was held at Copper Mountain, Colorado in 1992, originally entitled "The Cellular and Molecular Basis of Gastroduodenal Mucosal Defense", and subsequent meetings have taken place every three years since. The fourth and fifth meeting (2001 and 2004) were held at Chateau Montebello, Quebec, Canada. These later meetings introduced a broader scope to the program, which included investigation of gastrointestinal mucosal defense in the colon and entire small intestine as well as the upper gastrointestinal tract. This format, as well as the location, enhanced the success of the series. The proposed meeting, "Gastrointestinal Response to Injury: Canada 2007", addresses important and cutting edge topics relevant to diseases affecting the entire luminal GI tract. The program includes three parts each consisting of two separate sessions. Part I examines factors regulating gastrointestinal responses to injury including 1) the mucosal barrier, and 2) the immune system. The second part, agents and mechanisms of gastrointestinal injury addresses 3) NSAIDs, oxidative stress, and other agents of mucosal injury, and 4) microbial-host interactions. Part III addresses manifestations of gut injury and potential to modulate disease outcomes in sessions on 5) healing, repair, and carcinogenesis, and 6) chronic inflammation and its clinical consequences including inflammatory bowel disease. A major goal of this meeting is to provide young scientists with a unique exposure to current research in the field of gastrointestinal responses to injury in an open environment in which they can interact formally and informally with established investigators from around the world. The meeting will also foster interactions among scientists working in different aspects of gastroenteric biology as well as those between basic and clinical investigators. For the first time since 1998, the meeting has a major sponsor (the AGA Institute), in addition to support by educational grants from industry that will support costs of the meeting including travel, meals and accommodation for 26 invited speakers and/or session chairs comprised of 8 women, 5 racial/ethnic minorities (including 2 traditionally underrepresented minorities), and 6 junior investigators. This application requests funds needed to support the costs of attendance for young trainee investigators who otherwise might not have the opportunity to attend such a meeting. The aim of this application is to obtain the funds for travel awards to facilitate the participation of young scientists in "Gastrointestinal Response to Injury: Canada 2007."