Early Detection of Alzheimer's: Interdisciplinary and International Collaboration

描述（由申请人提供）：我们寻求NIA提供20,000美元的支持，以配合已筹集的37,500美元（包括来自希伯来大学的20,000美元），于2008年在以色列耶路撒冷举办会议，主题为“早期发现阿尔茨海默病：促进跨学科和国际交流与合作（第二届美国-以色列-巴勒斯坦联合大脑会议）”。这次会议是罗格斯大学的Mark Gluck与希伯来大学和圣城巴勒斯坦医学院合作组织的一系列国际神经科学和神经学会议中的第二次会议。在2008年的会议上，我们计划举办一场卫星会议，主题是“中东地区阿尔茨海默病的临床前景”，由圣城巴勒斯坦医学院主办，地点在耶路撒冷以东几英里的西岸校区。由Al Quds组织的这一卫星会议将包括来自约旦、以色列、埃及、摩洛哥、土耳其和巴勒斯坦领土的神经学家，讨论阿尔茨海默病诊断和治疗的区域临床问题，目的是促进进一步的区域临床和研究合作与交流（特别是以色列与其阿拉伯邻国之间）。2008年会议的主要科研项目将集中于与NIA直接相关的基础研究：阿尔茨海默病的早期检测。科学会议将在希伯来大学举行，并将回顾在了解阿尔茨海默病早期记忆丧失和脑损伤的大脑机制方面的新技术进展，以及跨学科和国际合作如何为早期阿尔茨海默病的未来新诊断和治疗提供信息。正如主要提案中更详细描述的那样，六个科学会议中的每一个都从不同的跨学科角度讨论了阿尔茨海默病的早期检测主题，包括(1)遗传学，(2)神经心理学，(3)药物开发，(4)神经影像学，(5)计算神经科学和(6)信息技术工具。会议将利用国际位置和广泛的跨学科和国际参与来探索，突出和促进来自几个不同学科的科学家和医生之间的交流和理解的新途径，这些科学家和医生都可以为与AD的早期发现（和治疗）有关的新实验和临床进展做出贡献。会议的国际组成部分——尤其是以色列医生、科学家、学生和博士后的广泛参与（无论是作为演讲者、海报展示者还是与会者），将扩大交流和未来的美以合作。会议将利用国际位置和广泛的跨学科和国际参与来探索，突出和促进来自几个不同学科的科学家和医生之间的交流和理解的新途径，他们都可以为与AD的早期发现（和治疗）有关的新的实验和临床进展做出贡献；会议的国际组成部分——特别是以色列医生、科学家、学生和博士后的广泛参与（无论是作为演讲者、海报展示者还是与会者），将扩大交流，促进未来的美以合作。

DESCRIPTION (provided by applicant): We seek $20,000 in support from NIA to match $37,500 already raised (including $20,000 from Hebrew University) to host a meeting in 2008, in Jerusalem, Israel, on the topic "Early Detection of Alzheimer's Disease: Promoting Interdisciplinary and International Communication and Collaboration (The 2nd Joint US-Israeli- Palestinian Brain Conference)". This meeting is the second in a series of international neuroscience and neurology meetings organized by Mark Gluck, of Rutgers University, in collaboration with Hebrew University and the Al Quds Palestinian Medical School. For the 2008 conference, we plan a satellite session on "Clinical Perspectives on Alzheimer's Disease in the Middle East" to be hosted by the Al Quds Palestinian Medical School, at their campus in the West Bank just a few miles east of Jerusalem. This satellite session, organized by Al Quds, will include neurologists from Jordan, Israel, Egypt, Morocco, Turkey, and the Palestinian territories speaking about regional clinical issues in Alzheimer's diagnosis and treatment, with the goal of promoting further regional clinical and research cooperation and communication (especially between Israel and her Arab neighbors). The main scientific research program for the 2008 meeting will focus on basic research of direct relevance to the NIA: Early detection of Alzheimer's disease. The scientific sessions will take place at Hebrew University and will review new technological advances in understanding the brain mechanisms of memory loss and brain damage in early stages of Alzheimer's disease, and how interdisciplinary and international collaboration can inform future novel diagnostics and therapeutics for early Alzheimer's disease. As described in more detail in the main proposal, each of the six scientific sessions addresses the topic of early detection of Alzheimer's disease from a different interdisciplinary perspective including (1) genetics, (2) neuropsychology, (3) drug development, (4) neuroimaging, (5) computational neuroscience, and (6) Information technology tools. The meeting will leverage the international location and broad interdisciplinary and international participation to explore, highlight, and promote new avenues of communication and understanding among scientists and doctors from several different disciplines who can all contribute to the creation of novel experimental and clinical advances relating to the early detection (and treatment) of AD. The international component of the meeting - especially the broad participation of Israeli doctors, scientists, students and postdoctoral fellows (both as speakers, poster-presenters, and attendees) will expand communication and future US-Israeli collaboration. The meeting will leverage the international location and broad interdisciplinary and international participation to explore, highlight, and promote new avenues of communication and understanding among scientists and doctors from several different disciplines who can all contribute to the creation of novel experimental and clinical advances relating to the early detection (and treatment) of AD; the international component of the meeting - especially the broad participation of Israeli doctors, scientists, students and postdoctoral fellows (both as speakers, poster-presenters, and attendees) will expand communication and promote future US-Israeli collaboration.