Risk Factors for Future Cognitive Decline and Alzheimer’s Disease in Older African Americans

老年非裔美国人未来认知能力下降和阿尔茨海默病的危险因素

• 批准号: 10516954
• 负责人: MARK A GLUCK
• 金额: $ 34.45万
• 依托单位: RUTGERS THE STATE UNIV OF NJ NEWARK
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-15 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10516954
• 关键词: Address; Administrative Supplement; Aerobic Exercise; Africa; African; African American; African American population; African ancestry; Age; Alzheimer' s Disease; Alzheimer' s disease risk; American; Behavioral; Blood; Candidate Disease Gene; Cognition; Cognitive; Comparative Study; Complex; Cross-Sectional Studies; Data Collection; Disease Outcome; Disease Progression; Education; Elderly; Epidemiology; Funding; Future; Gender; Genetic; Genetic Variation; Goals; Grant; Health; Health Alliance; Impaired cognition; Individual Differences; Knowledge; Lead; Life Style; Link; Medial; Mediating; Medical; Methods; Neurologist; Nigeria; Nigerian; Patient Recruitments; Patient Self-Report; Persons; Physical Fitness; Plant Roots; Population; Postdoctoral Fellow; Publishing; Race; Research Personnel; Risk; Risk Factors; Risk Marker; Site; Slave; Sleep; Temporal Lobe; United States National Institutes of Health; Universities; Validation; Variant; Work; aging brain; cognitive function; cognitive testing; cohort; comparative; data preservation; improved; innovation; lifestyle factors; longitudinal analysis; multidisciplinary; non-demented; nonEnglish language; novel; parent grant; physical therapist; prodromal Alzheimer' s disease; recruit; relating to nervous system; risk variant

PROJECT SUMMARY/ABSTRACT We seek to compare genetic/lifestyle interactions between African Americans and Nigerian Yoruba, using novel cognitive assessments of generalization developed at Rutgers, while linking individual differences in cognitive function on these tasks to variations in candidate genes. A majority of African American descendants of slaves have their ancestry (and hence, genetic variations) linked to the Yoruba people of West Africa. Understanding the similarities and differences in the interactions between genetic and lifestyle variations influencing MTL-specific cognition in older African Americans and older Yoruba will further illuminate complex determinants of AD risk and progression. This one year administrative supplement seeks to cross-validate current findings on risks of Alzheimer’s disease (AD) in African Americans with a different but similar and related population cohort—Yoruba people of West Africa by addressing a key question: Are African Americans and Yoruba people similar in their behavioral and neural risk markers for AD, specifically with regard to interactions between genetics (especially APOE and ABCA7) and modifiable health and lifestyle factors, especially physical fitness. With this supplemental funding we will expand the parent grant methods to collect blood from (a) 120 cognitively-healthy (non-demented) Yoruba, ages 60 and above, recruited at the University of Ibadan, and (b) compare genetic/lifestyle interactions between African Americans and Nigerian Yoruba, using novel cognitive assessments developed at Rutgers. The initial cross-sectional analysis will compare genetic/lifestyle interactions between African Americans and Nigerian Yoruba, using novel cognitive assessments of generalization developed at Rutgers, while linking individual differences in cognitive function on these tasks to variations in candidate genes. This will lead up to the longitudinal analysis (R01) assessing broader root causes of the high rates of cognitive decline and AD progression in older people of African ancestry.

项目总结/文摘