Risk Factors for Future Cognitive Decline and Alzheimer’s Disease in Older African Americans

项目总结/摘要 我们试图比较非裔美国人和尼日利亚约鲁巴人之间的遗传/生活方式相互作用， 使用罗格斯大学开发的新的泛化认知评估，同时将个体差异联系起来， 在这些任务中的认知功能与候选基因的变异有关。大多数非洲裔美国人 奴隶的后代有他们的祖先（因此，遗传变异）与西方的约鲁巴人有关。 非洲了解遗传和生活方式之间相互作用的异同 影响老年非裔美国人和老年约鲁巴人MTL特异性认知的变化将进一步阐明 AD风险和进展的复杂决定因素。 这份为期一年的行政补充报告旨在交叉验证目前关于阿尔茨海默氏症风险的发现 疾病（AD）在非洲裔美国人与一个不同的，但类似的和相关的人口队列约鲁巴人， 通过解决一个关键问题：非洲裔美国人和约鲁巴人在行为上相似吗？ 和AD的神经风险标志物，特别是关于遗传学（特别是APOE和 ABCA 7）和可改变的健康和生活方式因素，特别是身体健康。 有了这笔补充资金，我们将扩大父母补助金的方法，从（a）120 在伊巴丹大学招募的60岁及以上的认知健康（非痴呆）约鲁巴人，和（B） 比较非洲裔美国人和尼日利亚约鲁巴人之间的遗传/生活方式的相互作用，使用新的认知 罗格斯大学的评估。最初的横断面分析将比较遗传/生活方式 非洲裔美国人和尼日利亚约鲁巴人之间的互动，使用新的认知评估， 在罗格斯大学发展的概括，同时将这些任务中认知功能的个体差异与 候选基因的变异。这将导致纵向分析（R 01）评估更广泛的根源 非洲裔老年人认知能力下降和AD进展率高的原因。

PROJECT SUMMARY/ABSTRACT We seek to compare genetic/lifestyle interactions between African Americans and Nigerian Yoruba, using novel cognitive assessments of generalization developed at Rutgers, while linking individual differences in cognitive function on these tasks to variations in candidate genes. A majority of African American descendants of slaves have their ancestry (and hence, genetic variations) linked to the Yoruba people of West Africa. Understanding the similarities and differences in the interactions between genetic and lifestyle variations influencing MTL-specific cognition in older African Americans and older Yoruba will further illuminate complex determinants of AD risk and progression. This one year administrative supplement seeks to cross-validate current findings on risks of Alzheimer’s disease (AD) in African Americans with a different but similar and related population cohort—Yoruba people of West Africa by addressing a key question: Are African Americans and Yoruba people similar in their behavioral and neural risk markers for AD, specifically with regard to interactions between genetics (especially APOE and ABCA7) and modifiable health and lifestyle factors, especially physical fitness. With this supplemental funding we will expand the parent grant methods to collect blood from (a) 120 cognitively-healthy (non-demented) Yoruba, ages 60 and above, recruited at the University of Ibadan, and (b) compare genetic/lifestyle interactions between African Americans and Nigerian Yoruba, using novel cognitive assessments developed at Rutgers. The initial cross-sectional analysis will compare genetic/lifestyle interactions between African Americans and Nigerian Yoruba, using novel cognitive assessments of generalization developed at Rutgers, while linking individual differences in cognitive function on these tasks to variations in candidate genes. This will lead up to the longitudinal analysis (R01) assessing broader root causes of the high rates of cognitive decline and AD progression in older people of African ancestry.