Risk Factors for Future Cognitive Decline and Alzheimers Disease in Older African Americans

老年非裔美国人未来认知能力下降和阿尔茨海默病的危险因素

基本信息

  • 批准号:
    10739344
  • 负责人:
  • 金额:
    $ 153.92万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-05-15 至 2028-05-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY African Americans have double the prevalence of Alzheimer’s disease (AD) as compared to white Americans. We do not sufficiently understand the causes of this health disparity. In particular, there continues to be a dearth of data on the cognitive and neural changes that occur across the lifespan in older African Americans and how these relate to health and lifestyle, environmental, and genetic risk factors for AD. During the current grant cycle, we have shown that low levels of aerobic fitness and poor sleep quality may be key drivers of cognitive decline and AD in older African Americans. However, the impact of these potentially-modifiable health and lifestyle variables are not uniform across all individuals: rather, genetic variations and socio- environmental factors interact in complex ways to moderate how aerobic fitness and sleep quality influence brain health. To investigate these knowledge gaps further, we will leverage our track record of sixteen years (2006-2022) of deep community engagement through innovative partnerships with churches, senior centers, medical clinics, public housing and other organizations that serve the greater Newark, NJ area that has contributed to our success in enrolling older African Americans. Specifically, we will recruit 240 cognitively healthy participants ages 60 and above, and retest them in years 3 and 4 for their Cycle II (two-year) follow up. All participants who are age 80 or above will be tested every year, due to higher likelihood of decline within one year. Participants who show preliminary signs of cognitive decline—but not sufficient to be classified as mild cognitive impairment (MCI) or AD—will also be tested annually. Despite the deaths of almost 10% of our cohort from Covid-19, we still project carrying forward 290 participants from our current R01 and previous R56 for Cycle III (four-year), Cycle IV (six-year) and/or Cycle V (8-year) assessments. Thus, modulo attrition, we project a net cohort of 530 people for this study representing a longitudinally-followed cohort of older African Americans. In addition to our prior cognitive, health, lifestyle, genetic, and MRI assessments, we now include an expanded focus on Social Determinants of Health (SDOH) as well as the addition of two blood-based biomarkers for AD neuropathology: the ratio of 42 to 40 amino acid-long amyloid β, a marker of plaque pathology, and phosphorylated tau, a marker of AD-related tau phosphorylation and secretion. Our existing community engagement and research infrastructure will enable the following four new Specific Aims: (1) Examine whether aerobic fitness and sleep quality interact with genetic variations to influence cognitive performance, neural function, and neuropathology in older African Americans; (2) Expand methodologies for studying SDOH by assessing the predictive value of a novel measure of neighborhood disadvantage that is based on spatial proximity to abandoned buildings; (3) Evaluate our novel cognitive and neural markers as measures of prodromal AD; and (4) Determine how aerobic fitness and sleep quality interact with genetics to predict longitudinal changes in cognition and AD neuropathology as well as conversion to MCI or AD.
项目概要 与美国白人相比,非洲裔美国人的阿尔茨海默病 (AD) 患病率是白人的两倍。 我们还没有充分了解这种健康差异的原因。特别是,仍然存在 缺乏有关老年非裔美国人一生中认知和神经变化的数据 以及这些因素与 AD 的健康和生活方式、环境和遗传风险因素有何关系。当前期间 在拨款周期中,我们已经证明,有氧健身水平低和睡眠质量差可能是导致 老年非裔美国人的认知能力下降和 AD。然而,这些潜在可改变的影响 所有个体的健康和生活方式变量并不统一:相反,遗传变异和社会变异 环境因素以复杂的方式相互作用,以调节有氧健身和睡眠质量的影响 大脑健康。为了进一步调查这些知识差距,我们将利用我们十六年的记录 (2006-2022)通过与教堂、老年人中心的创新伙伴关系深入社区参与, 为新泽西州纽瓦克地区提供服务的医疗诊所、公共住房和其他组织 为我们成功招收老年非裔美国人做出了贡献。具体来说,我们将招募240名认知型 年龄 60 岁及以上的健康参与者,并在第 3 年和第 4 年重新进行测试,以进行第二周期(两年)随访。 所有 80 岁或以上的参与者每年都会接受测试,因为一年内衰退的可能性较大 年。表现出认知能力下降初步迹象的参与者,但不足以被归类为轻度 认知障碍 (MCI) 或 AD——也将每年进行一次测试。尽管我们的队列中有近 10% 的人死亡 从 Covid-19 起,我们仍计划将当前 R01 和之前 R56 中的 290 名参与者结转到 第三周期(四年)、第四周期(六年)和/或第五周期(8 年)评估。因此,以损耗为模数,我们 为这项研究规划了 530 人的净队列,代表纵向跟踪的非洲老年人队列 美国人。除了我们之前的认知、健康、生活方式、遗传和 MRI 评估之外,我们现在还包括 扩大对健康社会决定因素 (SDOH) 的关注,并增加了两种基于血液的因素 AD 神经病理学的生物标志物:42 至 40 个氨基酸长的淀粉样蛋白 β 的比率,斑块的标志物 病理学和磷酸化 tau 蛋白(AD 相关 tau 蛋白磷酸化和分泌的标志物)。我们现有的 社区参与和研究基础设施将实现以下四个新的具体目标:(1) 检查有氧健身和睡眠质量是否与遗传变异相互作用以影响认知 老年非裔美国人的表现、神经功能和神经病理学; (2) 扩展方法论 通过评估邻里劣势的新衡量标准的预测价值来研究 SDOH 基于与废弃建筑物的空间邻近性; (3) 将我们的新认知和神经标记评估为 前驱 AD 的测量; (4) 确定有氧健身和睡眠质量如何与遗传相互作用 预测认知和 AD 神经病理学的纵向变化以及向 MCI 或 AD 的转化。

项目成果

期刊论文数量(11)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
High-Quality Sleep Mitigates ABCA7-Related Generalization Deficits in Healthy Older African Americans.
  • DOI:
    10.3233/jad-230043
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    4
  • 作者:
    Sinha, Neha;Fausto, Bernadette A.;Mander, Bryce;Gluck, Mark A.
  • 通讯作者:
    Gluck, Mark A.
Increased dynamic flexibility in the medial temporal lobe network following an exercise intervention mediates generalization of prior learning.
运动干预后,内侧颞叶网络中的动态灵活性提高了先前学习的概括。
  • DOI:
    10.1016/j.nlm.2020.107340
  • 发表时间:
    2021-01
  • 期刊:
  • 影响因子:
    2.7
  • 作者:
    Sinha N;Berg CN;Yassa MA;Gluck MA
  • 通讯作者:
    Gluck MA
APOE ε4 status in healthy older African Americans is associated with deficits in pattern separation and hippocampal hyperactivation.
健康老年美国人的APOEε4状态与模式分离和海马过度激活的缺陷有关。
  • DOI:
    10.1016/j.neurobiolaging.2018.05.023
  • 发表时间:
    2018-09
  • 期刊:
  • 影响因子:
    4.2
  • 作者:
    Sinha N;Berg CN;Tustison NJ;Shaw A;Hill D;Yassa MA;Gluck MA
  • 通讯作者:
    Gluck MA
Cardio-Dance Exercise to Improve Cognition and Mood in Older African Americans: A Propensity-Matched Cohort Study.
有氧运动以改善非裔美国人的认知和情绪:一项倾向匹配的队列研究。
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MARK A GLUCK其他文献

MARK A GLUCK的其他文献

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{{ truncateString('MARK A GLUCK', 18)}}的其他基金

Risk and Resilience to Alzheimer’s Disease in African Americans
非裔美国人患阿尔茨海默病的风险和抵抗力
  • 批准号:
    10382510
  • 财政年份:
    2022
  • 资助金额:
    $ 153.92万
  • 项目类别:
Determinants of Individual Differences in the Efficacy of Aerobic Exercise to Improve Brain Health and Reduce Alzheimer Disease Risk in Older African Americans
有氧运动改善大脑健康和降低老年非裔美国人阿尔茨海默病风险的功效个体差异的决定因素
  • 批准号:
    10704183
  • 财政年份:
    2022
  • 资助金额:
    $ 153.92万
  • 项目类别:
Risk Factors for Future Cognitive Decline and Alzheimer's Disease in Older African Americans
老年非裔美国人未来认知能力下降和阿尔茨海默病的危险因素
  • 批准号:
    10368976
  • 财政年份:
    2018
  • 资助金额:
    $ 153.92万
  • 项目类别:
Risk Factors for Future Cognitive Decline and Alzheimer’s Disease in Older African Americans
老年非裔美国人未来认知能力下降和阿尔茨海默病的危险因素
  • 批准号:
    10516954
  • 财政年份:
    2018
  • 资助金额:
    $ 153.92万
  • 项目类别:
Risk Factors for Future Cognitive Decline and Alzheimer’s Disease in Older African Americans SUPPLEMENT
老年非裔美国人未来认知能力下降和阿尔茨海默病的危险因素补充
  • 批准号:
    9925973
  • 财政年份:
    2018
  • 资助金额:
    $ 153.92万
  • 项目类别:
Cognitive, Neural, and Immunological Consequences of COVID-19 in Older African Americans and How They Relate to Risk for Alzheimer’s Disease
COVID-19 对老年非裔美国人的认知、神经和免疫学影响及其与阿尔茨海默病风险的关系
  • 批准号:
    10267980
  • 财政年份:
    2018
  • 资助金额:
    $ 153.92万
  • 项目类别:
Risk Factors for Future Cognitive Decline and Alzheimer's Disease in Older African Americans
老年非裔美国人未来认知能力下降和阿尔茨海默病的危险因素
  • 批准号:
    9898203
  • 财政年份:
    2018
  • 资助金额:
    $ 153.92万
  • 项目类别:
Risk Factors for Future Cognitive Decline and Alzheimer's Disease in Older African Americans
老年非裔美国人未来认知能力下降和阿尔茨海默病的危险因素
  • 批准号:
    10603215
  • 财政年份:
    2018
  • 资助金额:
    $ 153.92万
  • 项目类别:
Risk Factors for Future Cognitive Decline and Alzheimer's Disease in Older African Americans
老年非裔美国人未来认知能力下降和阿尔茨海默病的危险因素
  • 批准号:
    10361580
  • 财政年份:
    2018
  • 资助金额:
    $ 153.92万
  • 项目类别:
Risk Factors for Future Cognitive Decline and Alzheimer's Disease in Older African Americans
老年非裔美国人未来认知能力下降和阿尔茨海默病的危险因素
  • 批准号:
    10116235
  • 财政年份:
    2018
  • 资助金额:
    $ 153.92万
  • 项目类别:

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Concurrent Aerobic Exercise and Cognitive Training to Prevent Alzheimer's in at-risk Older Adults
同时进行有氧运动和认知训练可预防高危老年人的阿尔茨海默病
  • 批准号:
    10696409
  • 财政年份:
    2023
  • 资助金额:
    $ 153.92万
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Effect of aerobic exercise-induced sleep changes on arterial stiffness associated with postprandial hyperglycemia.
有氧运动引起的睡眠变化对与餐后高血糖相关的动脉僵硬度的影响。
  • 批准号:
    23K10645
  • 财政年份:
    2023
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  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
The Effects of Aerobic Exercise on Cardiovascular Health in Postmenopausal Females: A Systematic Review and Meta-Analysis
有氧运动对绝经后女性心血管健康的影响:系统评价和荟萃分析
  • 批准号:
    480729
  • 财政年份:
    2023
  • 资助金额:
    $ 153.92万
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Aerobic Exercise Recommendations to Optimize Best Practices In Care after Stroke: AEROBICS 2024 Update
用于优化中风后护理最佳实践的有氧运动建议:AEROBICS 2024 更新
  • 批准号:
    480888
  • 财政年份:
    2023
  • 资助金额:
    $ 153.92万
  • 项目类别:
    Miscellaneous Programs
Supporting Aging through Green Exercise (SAGE): Comparing the cognitive effects of outdoor versus indoor aerobic exercise in older adults with mild cognitive impairment: A proof-of-concept randomized controlled trial
通过绿色运动支持老龄化 (SAGE):比较户外与室内有氧运动对患有轻度认知障碍的老年人的认知效果:概念验证随机对照试验
  • 批准号:
    495185
  • 财政年份:
    2023
  • 资助金额:
    $ 153.92万
  • 项目类别:
The influence of aerobic exercise on consolidation of fear extinction learning in PTSD
有氧运动对PTSD患者恐惧消退学习巩固的影响
  • 批准号:
    10840496
  • 财政年份:
    2023
  • 资助金额:
    $ 153.92万
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Improving Cognition Through Telehealth Aerobic Exercise and Cognitive Training After a First Schizophrenia Episode
在首次精神分裂症发作后通过远程医疗有氧运动和认知训练提高认知能力
  • 批准号:
    10647268
  • 财政年份:
    2023
  • 资助金额:
    $ 153.92万
  • 项目类别:
The influence of aerobic exercise on consolidation of fear extinction learning in PTSD
有氧运动对PTSD患者恐惧消退学习巩固的影响
  • 批准号:
    10630706
  • 财政年份:
    2023
  • 资助金额:
    $ 153.92万
  • 项目类别:
Examining Time and Nutrient Dependent Effects of Aerobic Exercise on Energy Metabolism in Adults with Overweight and Obesity
检查有氧运动对超重和肥胖成人能量代谢的时间和营养依赖性影响
  • 批准号:
    10886945
  • 财政年份:
    2023
  • 资助金额:
    $ 153.92万
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Enhancing cognitive function in breast cancer survivors through community-based aerobic exercise training
通过社区有氧运动训练增强乳腺癌幸存者的认知功能
  • 批准号:
    10691808
  • 财政年份:
    2023
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    $ 153.92万
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