The Molecular and Integrative Basis for Gastrointestinal Development, Homeostasis

描述（由申请人提供）： 在R13机制下请求提供资金，以部分支持第十二届两年一度的FASEB夏季会议，重点是胃肠道生物学，题为“GI Tract XII：GI发育，稳态和疾病的分子和综合基础”。会议将于2007年8月11日至16日在科罗拉多的斯诺马斯举行。这些会议于1985年发起，已成为以小型会议形式（100-200名与会者）讨论与胃肠道健康和疾病相关的前沿研究的主要场所之一。方案组织的两个独特方面为外地提供了特殊价值。一个纲领性的目标是汇集在不同领域工作的研究人员，以允许思想的交叉施肥，因此会议涵盖了广泛的主题。这是我们所知道的对胃肠道研究做出贡献的唯一小型会议形式。九个科学会议将围绕以下主题组织：了解GI功能的比较方法，干细胞，发育，沿隐窝/绒毛轴沿着分化，胃肠道病原体，炎症性肠病，癌症，离子转运/屏障和IBD疾病的遗传学。第二个计划目标是积极促进基础和临床科学家之间的互动。这是通过使用每个会议，以解决主题跨越健康的分子和细胞基础的胃肠道疾病，并再次是由一个小型会议的形式促进。科学，目标是（1）在消化系统疾病和相关领域的研究前沿提供科学规划，围绕这些疾病的潜在病理生理学和提供保护的机制组织，以及（2）在分子水平上整合信息，将阐明定义胃肠道器官水平行为的调节机制。该计划的组织，以提高经验和初级调查员（学生，研究员和教师到助理教授的职级）的参与，通过将他们纳入短期讲座的讲座计划作为一个抽象的驱动竞争的结果初级调查员演讲奖。我们的资金请求是专门支持这个奖励计划，让更多的初级研究人员积极参与该计划。这项建议旨在继续1985年开始的两年期会议。本次会议的目的是提供最新的信息，在正常和病变组织的胃肠道研究紧迫的相关主题。组织者跨越了从基础研究到病理学的广泛领域，并建立了一个基于基本原则的计划，即每次会议都应展示技术和概念创新，为研究人员提供新的知识见解，以推进他们自己的研究计划，无论胃肠道生物学中的具体子学科是什么。

DESCRIPTION (provided by applicant): Funding is requested under the R13 mechanism in partial support for the twelfth biennial FASEB summer conference focused on gastrointestinal biology, entitled "GI Tract XII: The Molecular and Integrative Basis for GI Development, Homeostasis and Disease". The meeting will be held in Snowmass Colorado on August 11-16, 2007. Initiated in 1985, these conferences have become one of the premier venues for the discussion of cutting-edge research related to gastrointestinal health and disease in a small meeting format (100-200 attendees). Two unique aspects of the programmatic organization provide special value to the field. One programmatic goal is to bring together researchers working in disparate fields to allow cross-fertilization of ideas, therefore a broad set of topics is covered at the meeting. This is the only small-meeting format of which we are aware that makes this contribution to gastrointestinal research. The nine scientific sessions will be organized around the topics of: Comparative Approaches to Understanding GI Function, Stem Cells, Development, Differentiation Along the Crypt/Villus Axis, Gastrointestinal Pathogens, Inflammatory Bowel Disease, Cancer, Ion Transport/Barrier, and The Genetics of IBD Disorders. The second programmatic goal is active promotion of interactions between basic and clinical scientists. This is achieved by using each session to address topics spanning the molecular and cellular basis of health to disease in the GI tract, and again is facilitated by a small-meeting format. Scientifically, goals are to (1) provide scientific programming at the forefront of research in digestive diseases and related areas, organized around the underlying pathophysiology of these diseases and the mechanisms that afford protection against them, and (2) to integrate information at the molecular level that will shed light on regulatory mechanisms that define the organ-level behavior of the gastrointestinal tract. The program is organized to enhance the experience and involvement of junior investigators (students, fellows, and faculty up to the rank of Assistant Professor), by incorporating them into the lecture program in short lectures as a result of an abstract-driven competition for Junior Investigator Speaker awards. Our funding request is specifically to support this award program allowing more Junior Investigators to participate actively in the program. This proposal seeks to continue a biannual meeting started in 1985. The purpose of this conference is to provide the latest information on topics of pressing relevance to gastrointestinal research in both normal and diseased tissues. The organizers span a broad range of domains from basic research to pathology, and have built a program on the basic precept that every session should demonstrate technical and conceptual innovation that will provide investigators with new intellectual insights to advance their own research programs no matter what the specific subdiscipline within gastrointestinal biology.