FASEB Summer Conference on Phospholipases

描述(由申请人提供)： 本申请寻求为将于2006年7月8日至13日在佛蒙特州萨克斯顿河举行的第八届FASEB关于磷脂酶的夏季研究会议提供部分资金。所要求的资金将主要用于支持初级调查人员的注册和旅费，他们将在会议上以应邀陈述、简短演讲或海报的形式介绍他们的工作。这次会议的总体目标是提供一个论坛，回顾和讨论最近关于磷脂酶的结构、功能和整合生物学的研究。这些广泛表达的酶可以水解膜磷脂中的酯和磷酸二酯键，产生生物活性脂质和脂类衍生产品，调节细胞功能的许多不同方面。磷脂酶A产生脂肪酸和受体活性溶血磷脂。花生四烯酸被代谢成白三烯和前列腺素，它们在生理和病理过程中具有广泛的作用，如肾脏灌流、胃细胞保护、止血、癌症、宿主防御、炎症和哮喘。磷脂酶C在激动剂激活细胞表面受体后产生肌醇磷酸和二甘油酯第二信使。磷脂酶D由磷脂酰胆碱产生磷脂酸，调节肌动蛋白细胞骨架的组织、细胞的生长、存活、运动和囊泡运输。会议包括关于信号网络和脂类组学以及鞘脂的新兴领域的演讲，这些领域在细胞应激反应、细胞凋亡和细胞迁移中发挥作用。这次会议汇集了在不同学科工作的科学家，包括生物物理学、结构、细胞和分子生物学、药物开发和受磷脂酶研究影响的不同临床学科。这次会议的良好记录包括国际调查人员的贡献，以及初级和资深调查人员的介绍。它为促进该领域的合作和新进展提供了一个有效的论坛。该主题领域得到了国家卫生研究院的大量支持，每个主要的国家卫生研究院都资助了大约400个正在进行的项目。在过去10年中，该领域每年都发表了大约2000份同行评审的研究出版物。这项提议所要求的资金将对支持本次会议，特别是青年研究人员的发展作出宝贵贡献。

DESCRIPTION (provided by applicant): This application seeks partial funding for the eighth FASEB Summer Research Conference on Phospholipases to be held from July 8 to 13, 2006 in Saxtons River, Vermont. The funds requested will be used primarily to support the registration and travel expenses of junior investigators who will present their work at the conference as invited presentations, short talks, or posters. The overall goal of this established and successful conference is to provide a forum for review and discussion of recent research on the structure, function and integrated biology of phospholipases. These widely expressed enzymes hydrolyze ester and phosphodiester bonds in membrane phospholipids to generate bioactive lipids and lipid-derived products that regulated many and diverse aspects of cell function. Phospholipases A generate fatty acids and receptor-active lysophospholipids. Arachidonic acid is metabolized to leukotrienes and prostaglandins that have well established roles in physiologic and pathologic processes such as renal perfusion, gastric cytoprotection, hemostasis, cancer, host defense, inflammation, and asthma. Phospholipase C generates inositol phosphate and diglyceride second messengers in response to agonist activation of cell surface receptors. Phospholipase D generates phosphatidic acid from phosphatidylcholine, to regulate organization of the actin cytoskeleton, cell growth, survival, motility and vesicular transport. The conference includes talks on the emerging areas of signaling networks and lipidomics as well as sphingolipids, which have roles in cellular stress responses, apoptosis, and cell migration. This conference brings together scientists working in diverse disciplines including biophysics, structural, cell and molecular biology, drug development, and diverse clinical disciplines that are impacted by research on phospholipases. The conference has a strong record of including contributions from international investigators and of including presentations from both junior and established investigators. It provides an effective forum for promoting collaborations and new advances in the field. The subject area receives considerable support from the NIH with approximately 400 active projects funded by each of the major NIH institutes. The field has generated approximately 2000 peer reviewed research publications in each of the last 10 years. The funds requested in this proposal will make an invaluable contribution to the support of this conference and in particular the development of young investigators.