Genetic pathology of Roquin in human autoimmune disease

狼疮是一种危及生命的疾病，其中通常针对细菌的免疫反应针对体内组织。我们已经发现了狼疮的小鼠模型，并阐明了决定免疫力是针对身体还是细菌的重要途径。基于最近在理解个体之间遗传变异方面的进展，我们将使用从小鼠模型中获得的信息来研究调节狼疮患者这一途径的基因。

Lupus is a life-threatening disease in which immune responses normally targeted at germs are directed at tissue in the body. We have discovered a mouse model of lupus and elucidated an important pathway that determines whether immunity is directed at the body or at germs. Building on recent progress in understanding the genetic variation between individuals, we will use the information obtained from the mouse model to investigate the genes that regulate this pathway in people with lupus.