fRMI Studies of Emotion and Cognition

描述（由申请人提供）：这是一个K 02独立科学家奖更新的修订申请。在最初的奖励期间，PI获得了功能性磁共振成像（fMRI）的专业知识。技能发展的重点是学习功能磁共振成像方法的基本方面，增加人类神经解剖学的知识，开发在功能磁共振成像过程中使用的激活任务，特别是研究精神分裂症的神经病理学，并学习使用耶鲁功能磁共振成像中心开发的图像处理和数据分析软件。K 02更新期间的技能发展有两个目标：1）获得研究区域间结构和功能连接所需的技能; 2）学习使用由研究小组开发的图像分析软件，而不是PI一直合作的耶鲁小组。 在最初供资期间完成的工作已导致发表18篇同行评审的研究论文，另有5篇研究论文目前正在审查中。PI是其中9篇论文的第一作者和11篇论文的高级作者。 在此期间，他一直是9名年轻研究人员的主要研究导师。他们获得了1 R 01赠款和3基金会赠款，他是高级合作研究员，以及1 B-START和5 NARSAD青年研究员奖，他是主要导师。另一个R 01赠款是重新提交后，令人鼓舞的审查。 这项研究几乎完全来自两个资助的R 01项目。在一种情况下，申请人是PI;在另一种情况下，他是合作研究者，他的同事Morris Bell是PI。第一个R 01支持使用记忆测试，结构MRI和fMRI来亚型精神分裂症的持续工作。第二个项目支持继续开发和评估计算机化练习，以治疗精神分裂症患者的认知缺陷。 这两个项目都提供了发展和应用测量区域间大脑连接和使用新分析软件的技能的机会。

DESCRIPTION (provided by applicant): This is a revised application for renewal of a K02 Independent Scientist Award. During the initial award period, the PI gained expertise in functional magnetic resonance imaging (fMRI). Skill development focused on learning basic aspects of fMRI methodology, increasing knowledge of human neuroanatomy, developing activation tasks for use during fMRI with particular relevance for studying the neuropathology of schizophrenia, and learning to use the image processing and data analysis software developed at the Yale fMRI Center. Skill development during the requested K02 renewal has two goals: 1) to acquire skills necessary to study inter-regional structural and functional connectivity; and 2) to learn to use image analysis software developed by research groups other than the Yale group with which the PI has been working. Work done during the initial funding period has led to 18 published peer-reviewed research papers and 5 more research papers are currently under review. The PI is first author on 9 of these papers and senior author on 11. During this period he has been the primary research mentor for 9 younger researchers. They have received 1 R01 grant and 3 foundation grants on which he is the senior co-investigator, and 1 B-START and 5 NARSAD Young Investigator Awards on which he is the primary mentor. Another R01 grant is being resubmitted after an encouraging review. The proposed research comes almost entirely from two funded R01 projects. On one the applicant is the PI; on the other he is the co-investigator and his colleague, Morris Bell, is the PI. The first R01 supports continued work using memory tests, structural MRI and fMRI to subtype schizophrenia. The second project supports continued development and evaluation of computerized exercises to treat the cognitive deficits in people with schizophrenia. Both projects provide opportunities to develop and apply skills in measurement of inter-regional brain connectivity and in use of new analytic software.