Virology of the Central Nervous System

描述(由申请者提供)：该计划的目的是提供最先进的博士后基础研究培训，旨在了解病毒感染和中枢神经系统疾病的机制。该计划已经扩大到包括14名老牌和资金充足的科学家担任导师，他们共同感兴趣的是了解在各种病毒系统中感染CMS病毒的后果。该计划的持续承诺是培养精通分子和细胞生物学，并拥有足够的技能和知识来开发神经病毒学领域富有成效的独立计划的高能力和独立的研究人员。培训项目为学员的职业发展提供了便利：1)在经验丰富的资深科学家的指导下提供全职研究经验；2)最先进的设备和技术的使用指导；3)研究所工作人员或特邀演讲者每周举办4-5场研讨会，有机会与来访的科学家和教职员工会面，交流神经病毒学和相关领域的想法；4)有机会进行神经生物学、分子生物学、病毒学和免疫学的正式学习；以及5)研究员每年至少有一次机会展示自己的研究成果，供其他研究员和工作人员批评。受训者来自一批合格的医学博士、博士和医学博士申请者，其依据是1)以前的学术和调查表现；2)致力于生物医学研究的证据，特别是中枢神经系统的病毒疾病；以及3)以前导师的推荐。任命将至少为两年，正常情况下为三年。与公共卫生的相关性：随着艾滋病毒/艾滋病的持续流行，以及其他病毒病原体的出现/重新出现，包括汉坦病毒、西尼罗河病毒、马脑炎病毒、麻疹、脊髓灰质炎病毒和许多其他潜在的传染病病原体，显然将继续迫切需要精通中枢神经系统感染的分子病毒学家。因此，这一培训计划的总体相关性很高。

DESCRIPTION (provided by applicant): The purpose of this program is to provide state-of-the-art postdoctoral training in basic research directed at understanding the mechanisms of virus infection and disease in the central nervous system. The program has expanded to include fourteen established and well-funded scientists to act as mentors, with the common interest of understanding the consequences of virus infection of the CMS in a wide variety of viral systems. The continued commitment of the program is to train highly competent and independent researchers that are well-versed in molecular and cell biology and that possess skills and knowledge sufficient to develop productive independent programs in the area of neurovirology. Career development of the trainees is facilitated by a training program that provides 1) full-time research experience under the guidance of experienced senior scientists; 2) instruction in the use of state-of-the-art equipment and technologies; 3) an intellectual environment that provides 4-5 seminars per week by the Institute staff or invited speakers, with opportunities to meet with visiting scientists and faculty members and exchange ideas in neurovirology and related fields; 4) opportunity for formal studies in neurobiology, molecular biology, virology, and immunology; and 5) opportunity for fellows to present their own research findings for critique by other fellows and staff scientists at least once a year. Trainees are from a pool of qualified M.D., Ph.D., and D.V.M. applicants on the basis of 1) previous Academic and investigative performance; 2) evidence of commitment to biomedical research, in particular to virus diseases of the CNS; and 3) recommendations from previous mentors. Appointments will be for a minimum of two years, with three years the norm. Relevance to Public Health: With the continuing HIV/AIDS epidemic and the emergence/re-emergence of other viral pathogens including Hantavirus, West Nile, equine encephalitis virus, measles, poliovirus, and a host of other potential infectious agents, it is clear that there will continue to be a strong need for molecular virologists versed in infections of the CNS. Thus, the overall relevance of this training program is high.