A Device for PET Tracer Development and Production

描述（由申请人提供）：巨大的技术和生物医学进步正在推动分子水平生理功能成像的急剧增加。这些包括临床质量的PET/CT仪器、uPET和现在具有迄今为止无法实现的能力的uPET/CT设备。与这些进展紧密相关的是基于正电子发射放射性核素的放射性药物阵列的伴随发展，这些放射性药物非常适合探索神经科学，癌症和心血管疾病过程以及心理-精神问题。预计这些发展，我们正在开发一个主要的新的研究设施，其中成像科学是一个重要的核心组成部分。围绕这一能力，将在癌症，神经科学，心血管和再生医学研究广泛的计划。服务所有是一个国家的最先进的动物园，包括我们的灵长类动物中心的扩展。在图像科学中心，我们正在为一个主要的PET放射性药物生产设施建造空间，周围环绕着一系列小动物和人类成像设备。这整个设施是紧密耦合到我们相邻的临床设施，以实现最高水平的整合和翻译的护理，诊断和预防。在本提案中，我们寻求对基本放射性核素生产和制药/开发设备的支持。该设施的所有其他方面和费用，包括建筑费用，都由该机构承担。凭借我们三十年的PET经验和广泛而多样化的用户基础，我们将拥有一个具有广泛能力的卓越科学敏捷性的设施。

DESCRIPTION (provided by applicant): Enormous technological and biomedical advances are driving a dramatic increase in molecular level physiological functional imaging. These include clinical quality PET/CT instruments, uPET and now uPET/CT devices with heretofore unattainable capabilities. Tightly coupled to these advances are concomitant developments of an array of radiopharmaceuticals based on positron emitting radionuclides that are highly suited to exploring neuroscience, cancer, and cardiovascular disease processes as well as psychological-psychiatric issues. Anticipating these developments, we are developing a major new research facility of which imaging science is a significant core component. Surrounding this capability will be sited extensive programs in cancer, neuroscience, cardiovascular, and regenerative medicine research. Servicing all is a state-of-the-art vivarium including an extension of our primate center. In the image science center we are building space for a major PET radiopharmaceutical production facility surrounded by a spectrum of small animal and human imaging devices. This entire facility is tightly coupled to our adjacent clinical facilities to achieve the highest level of integration and translation to care, diagnosis, and prevention. In this proposal, we seek support for the essential radionuclide production and pharmaceutical fabrication/development equipment. All other aspects and costs of the facility, including construction, are being born by the institution. With our three decades of PET experience and the broad and diverse user base, we will have a facility of excellent scientific agility with broad capability.