Imaging-based fluid-structure interaction modelling of carotid atherosclerotic plaque

本项目旨在结合计算建模、磁共振成像（MRI）、力学测量和病理分析来研究颈动脉斑块的进展，量化可能发生斑块破裂的临界血流量和斑块应力/应变条件。基于磁共振成像的三维计算模型，包括多组分斑块结构及其与血流的相互作用，将被开发和数值求解，以确定合适的斑块破裂风险指标。斑块成分的机械性能将在体外测量，基于纤维取向的本构规则将被开发。该项目旨在定量了解斑块的进展和破裂。

This project aims to combine computational modelling, magnetic resonance imaging (MRI), mechanical measurement and pathological analysis to investigate carotid plaque progression, and quantify the critical blood flow and plaque stress/strain conditions under which plaque rupture is likely to occur. MRI-based 3D computational models with multi-component plaque structures and their interaction with blood flow will be developed and solved numerically to identify suitable plaque rupture risk indicators. Mechanical properties of plaque components will be measured ex-vivo and fibre orientation-based constitutive rules will be developed. This project aims to lead to quantitative understandings of plaque progression and rupture.