Training in Molecular Basis of Skin Pathobiology

描述（由申请人提供）：俄勒冈州健康与科学大学皮肤科系提出了一个新的培训计划，目标是培养高素质的博士前和博士后在皮肤基础和转化研究的学术生涯。OHSU皮肤科拥有强大的临床和科学研究历史，并在皮肤科住院医师培训方面有40年的记录。拟议方案的特点是：1）皮肤科教师的核心，包括项目主任Kulesz-Martin博士（皮肤癌发生，肿瘤抑制因子p53），联合主任王晓静（皮肤癌发生的表皮基因开关转基因模型和皮肤病中的TGF-β/SMAD通路），分别拥有24年和14年的皮肤研究和指导经验，Steven Jacques（皮肤光学成像）和Melissa Wong（β-连环蛋白通路，干细胞），2）一个多学科的科学家团队，在与皮肤细胞生长、分化和凋亡高度相关的领域获得国际认可，包括卢华（第63页和第53页），布鲁斯马贡（TGF-β和应激激酶反应），Peter Rotwein（分化中的胰岛素样生长因子/IGF，组织生长和再生）和菲利普·斯托克（Ras和B-Raf信号在生长和凋亡中的作用）和3）新设计的研究空间，总面积约为6000平方英尺（4500平方英尺的皮肤科和1500平方英尺的OHSU癌症研究所空间）。三名博士后和两名博士前培训生将从医学博士，博士或医学博士/希望从事皮肤病学研究或基础皮肤研究的博士候选人，具有较强的临床转化成分。标准将包括独立性的潜力，推荐信，出版记录，在皮肤病学和接触服务不足的少数民族的强大潜力的影响的专业知识。培训计划包括OHSU的研究生课程，导师部门（皮肤病学，细胞与发育生物学，生物化学，分子与医学遗传学）的研讨会，每月皮肤病学研究部门会议和技术研讨会，为博士前或博士后学生量身定制的研究论坛以及皮肤生物学的国家/国际会议。

DESCRIPTION (provided by applicant): The Oregon Health & Science University Department of Dermatology proposes a new training program with objectives to train highly qualified predoctoral and postdoctorals for academic careers in skin basic and translational research. The OHSU Dermatology Department has a strong history of clinical and scientific research and a 40 year record in dermatology resident training. Features of the proposed program are: 1) a core of Dermatology faculty, including program director Dr. Kulesz-Martin (skin carcinogenesis, tumor suppressor p53), and Co-Director Xiao-Jing Wang (epidermal gene-switch transgenic models of skin carcinogenesis and TGF-beta/SMAD pathways in skin disease) with 24 and 14 years experience in skin research and mentorship, respectively, Steven Jacques (cutaneous optical imaging), and Melissa Wong (Beta-catenin pathway, stem cells), 2) a multidisciplinary team of scientists with international recognition in areas highly relevant to skin cellular growth, differentiation and apoptosis, including Hua Lu (p63 and p53), Bruce Magun (TGF-beta and stress kinase responses), Peter Rotwein (insulin-like growth factors/IGFs in differentiation, tissue growth and regeneration) and Philip Stork (Ras and B-Raf signaling in growth and apoptosis) and 3) newly designed research space totaling approximately 6000 sq ft (4500 sq ft in Dermatology and 1500 sq ft of OHSU Cancer Institute space). Three postdoctoral and two pre-doctoral trainees will be selected from M.D., Ph.D. or M.D./PhD candidates who desire an academic career in investigative dermatology or basic skin research with strong clinical translational component. Criteria will include potential for independence, letters of recommendation, publication record, expertise of strong potential for impact in dermatology and outreach to underserved minorities. The training program includes graduate courses at OHSU, seminars in mentors' departments (Dermatology, Cellular & Developmental Biology, Biochemistry, Molecular & Medical Genetics), monthly Dermatology Research Division meetings and techniques seminars, research forums tailored to predoctoral or postdoctoral students and national/international meetings in cutaneous biology.