Comprehensive Training Grant in Bone Biology and Disease

描述（由申请人提供）：DAB骨生物学和疾病综合研究培训计划的竞争性更新，为能够进行创新骨相关研究的独立研究科学家的发展提供了严格的跨学科教育。项目成立4年来，已有1名博士前实习生（现为种植生物学和材料研究博士后）和5名博士后（包括1名学术临床医生）完成；其中4人从事骨生物学研究，3人在学术界，1人在工业界。该项目利用了uab代谢性骨病中心（主任：J. McDonald， MD）的资源和研究基地，该中心是美国五个p30资助的骨项目之一。培训计划的33名导师是根据他们在临床和基础研究方面的互补研究专长、动态研究项目和示范性培训记录选择的。现有的基础研究项目包括利用新模型结合尖端技术分析骨质流失的基本生物学；骨质疏松症、其他代谢性骨病、糖皮质激素引起的骨质流失、牙病、转移性骨病和骨肉瘤；生物材料植入/研究;基因治疗转移技术。临床研究项目（流行病学、预防、结果和有效性研究；诊断的发展；和临床试验）利用临床教师参与长期的、多机构的研究。培训计划由McDonald博士（病理学主席）在两名副主任和一个咨询委员会的协助下管理。基础研究的学员需要全部或部分参加综合生物医学科学（IBS）课程，该课程提供基于器官和细胞的基础科学培训，从方法驱动的分子生物学和遗传学分析过渡到临床相关的、基于问题的研究。博士预科学员将被录取到UAB的IBS、生物医学工程、细胞和分子生物学或医学博士/博士研究生课程。在过去的四年中，通过战略性招聘，骨骼相关课程得到了扩展，师资队伍也得到了加强。对骨骼研究的持续机构承诺导致了UAB最先进设施的大规模扩展和新的跨学科项目的发展，进一步加强了研究基础和课程。申请资助3名博士预科生和3名博士后。相关：本专业培养应用尖端分子和细胞方法来发现、开发和测试治疗方法的科学家，用于预防和治疗骨质疏松症、类风湿性关节炎和其他疾病相关的骨质流失，促进骨伤口愈合，以及开发具有更大生物相容性和更长寿的骨科和牙科植入物。

DESCRIPTION (provided by applicant): This competitive renewal of the comprehensive Research Training Program in Bone Biology and Disease at DAB provides the rigorous interdisciplinary education required for the development of independent research scientists capable of innovative bone-related research. Since its establishment four years ago, one predoctoral trainee, who is now a postdoctoral fellow in implant biology and materials research, and five post-doctoral students, including an academic clinician, have completed the program; four of whom are pursuing bone biology research, three in academics and one in industry. The Program leverages the resources and research base of in the UAB-Center for Metabolic Bone Disease (Director: J. McDonald, MD), one of five P30-funded bone programs in the nation. The 33 preceptors of the Training Program have been selected based on their complementary research expertise in clinical and basic research, dynamic research programs, and exemplary training records. Available basic research projects include the use of novel models combined with cutting-edge technologies in the analysis of the basic biology of bone loss; osteoporosis, other metabolic bone diseases, and glucocorticoid-induced bone loss, dental disease, metastatic bone disease and osteosarcoma; biomaterials/implant research; and gene therapy transfer technology. The clinical research projects (epidemiology, prevention, outcomes, and effectiveness studies; development of diagnostics; and clinical trials) exploit the participation of clinical faculty in long-term, multi-institutional studies. The Training Program is administered by Dr. McDonald (Chair: Pathology) with the assistance of two Associate Directors, and an Advisory Committee. Trainees in basic research are required to take all or part of the Integrative Biomedical Sciences (IBS) Program, which provides organ- and cell-based basic science training necessary for transition from methods-driven molecular biology and genetics analyses into clinically-relevant, problem-based studies. Predoctoral trainees are enrolled in the IBS, Biomedical Engineering, Cellular and Molecular Biology, or MD/PhD Graduate Programs at UAB. In the past four years, the bone-related curriculum has been expanded and the faculty strengthened through strategic recruitment. The ongoing institutional commitment to bone research has resulted in a major expansion of state-of-the-art facilities and the development of new interdisciplinary programs at UAB that further strengthen the research base and curriculum. Funding is requested for three predoctoral and three postdoctoral trainees. Relevance: This program produces scientists who apply cutting edge molecular and cellular approaches to the discovery, development, and testing of therapeutics for the prevention and treatment of bone loss associated with osteoporosis, rheumatoid arthritis, and other diseases, and the promotion of bone wound healing, as well as the development of orthopedic and dental implants with greater biocompatibility and longevity.