Training: Hematology, Immunology & Stem Cell Biology

这是第二次重新提交博士后血液学培训的竞争性续签申请。 该计划位于儿童医院奥克兰研究所(CHORI)。该程序提供了 血液学、免疫学、遗传学、造血干细胞生物学的研究培训机会 移植，重点是这些学科在血红蛋白病中的应用。这 申请每年需要三名实习生。该计划将强调实际操作和临床实践。 在有经验的NIH支持的研究人员的实验室或临床环境中的研究工作。一个 委员会将参与候选人的遴选和评估，以及实验室 任务。具有博士、医学博士或医学博士学位的合格实习生将被录用，且具有较强的 背景和兴趣：细胞或分子生物学、遗传学、生物化学、移植生物学或 临床研究。在奖学金的开始，每个受训者将发展一个研究假设和 写一份研究计划，由董事和导师审阅和批准。实习生将 参与核心课程活动，每天与导师会面，每月与项目总监会面。 学员将完成伦理学和统计学方面的授课课程，并有机会参加高级课程 比如分子生物学和干细胞生物学。学员将参加每周一次的实验室会议， 月刊俱乐部和每周研究研讨会。受训者将在国家会议上展示他们的研究 科学会议，在同行评议的期刊上发表几篇手稿，并开始寻找外部 在他们的第二年给予支持。美国国立卫生研究院在CHORI资助的领域的研究机会 包括：(1)镰状细胞性贫血和地中海贫血的临床研究；(2)红细胞膜结构和 功能，(3)免疫发展和对疫苗的免疫反应，(4)生物铁，分子调控 铁蛋白合成与铁毒，(5)干细胞生物学中脂质介导的信号转导，(6)遗传 疾病严重程度的多态，(7)脐带血干细胞生物学，和(8)干细胞 用于血红蛋白病患者的移植。完成培训后，学员将准备继续 在血红蛋白疾病领域的学术环境中工作，并成为合格的、独立的 科学家

This is the second resubmission of a competitive renewal application for a post-doctoral hematology training program located at Children's Hospital Oakland Research Institute (CHORI). The program provides the opportunity for research training in hematology, immunology, genetics, hematopoietic stem cell biology, and transplantation with a focus on the application of these disciplines to the hemoglobinopathies. This application requests three trainees per year. The program will emphasize hands-on bench and clinical research work in the laboratory or clinical setting of an experienced, NIH-supported investigator. A committee will participate in the selection and evaluation of candidates, as well as in the laboratory assignment. Eligible trainees with PhD, MD/PhD or MD degrees will be recruited who have a strong background and interest in cell or molecular biology, genetics, biochemistry, transplantation biology or clinical research. At the beginning of the fellowship, each trainee will develop a research hypothesis and write a research proposal, which will be reviewed and approved by the directors and mentors. Trainees will participate in core curriculum activities, meet daily with mentors, and monthly with program directors. Trainees will complete didactic coursework in ethics and statistics, and have access to advance courses such as molecular biology and stem cell biology. Trainees will participate in weekly laboratory meetings, monthly journal clubs and weekly research seminars. Trainees will present their research at national scientific meetings, publish several manuscripts in peer-reviewed journals, and begin to seek extramural grant support during their second year. The research opportunities in areas funded by NIH at CHORI include: (1) clinical research in sickle cell anemia and thalassemia, (2) red cell membrane structure and function, (3) immunologic development and immune response to vaccines, (4) bioiron, molecular regulation of ferritin synthesis, and iron toxicity, (5) lipid mediated signal transduction in stem cell biology, (6) genetic polymorphisms contributing to disease severity, (7) cord blood stem cell biology, and (8) stem cell transplantation for patients with hemoglobinopathies. Upon completion, trainees will be prepared to continue to work in an academic setting in the field of hemoglobinopathies and become qualified, independent scientists