Training: Hematology, Immunology & Stem Cell Biology

描述（由申请人提供）： 这是第二次重新提交位于奥克兰儿童医院研究所（CHORI）的博士后血液学培训项目的竞争性更新申请。该计划提供了在血液学，免疫学，遗传学，造血干细胞生物学和移植研究培训的机会，重点是这些学科的血红蛋白病的应用。该应用程序每年需要三名受训人员。该计划将强调在实验室或经验丰富的NIH支持的研究人员的临床环境中进行实验室和临床研究工作。一个委员会将参与候选人的选择和评估，以及实验室分配。将招募具有博士，MD/PhD或MD学位的合格学员，他们在细胞或分子生物学，遗传学，生物化学，移植生物学或临床研究方面具有强大的背景和兴趣。在奖学金开始时，每个学员将制定一个研究假设，并编写一份研究计划，这将由董事和导师审查和批准。学员将参加核心课程活动，每天与导师见面，每月与项目主管见面。学员将完成伦理学和统计学的教学课程，并有机会获得先进的课程，如分子生物学和干细胞生物学。学员将参加每周的实验室会议，每月的期刊俱乐部和每周的研究研讨会。受训者将在国家科学会议上介绍他们的研究，在同行评审的期刊上发表几篇手稿，并在第二年开始寻求校外资助。在由NIH资助的领域在CHORI的研究机会包括：（1）镰状细胞性贫血和地中海贫血的临床研究，（2）红细胞膜结构和功能，（3）免疫发育和对疫苗的免疫应答，（4）生物铁，铁蛋白合成的分子调节和铁毒性，（5）干细胞生物学中脂质介导的信号转导，（6）影响疾病严重程度的遗传多态性，（7）脐带血干细胞生物学，和（8）血红蛋白病患者的干细胞移植。完成后，学员将准备继续在血红蛋白病领域的学术环境中工作，并成为合格的独立科学家。

DESCRIPTION (provided by applicant): This is the second resubmission of a competitive renewal application for a post-doctoral hematology training program located at Children's Hospital Oakland Research Institute (CHORI). The program provides the opportunity for research training in hematology, immunology, genetics, hematopoietic stem cell biology, and transplantation with a focus on the application of these disciplines to the hemoglobinopathies. This application requests three trainees per year. The program will emphasize hands-on bench and clinical research work in the laboratory or clinical setting of an experienced, NIH-supported investigator. A committee will participate in the selection and evaluation of candidates, as well as in the laboratory assignment. Eligible trainees with PhD, MD/PhD or MD degrees will be recruited who have a strong background and interest in cell or molecular biology, genetics, biochemistry, transplantation biology or clinical research. At the beginning of the fellowship, each trainee will develop a research hypothesis and write a research proposal, which will be reviewed and approved by the directors and mentors. Trainees will participate in core curriculum activities, meet daily with mentors, and monthly with program directors. Trainees will complete didactic coursework in ethics and statistics, and have access to advance courses such as molecular biology and stem cell biology. Trainees will participate in weekly laboratory meetings, monthly journal clubs and weekly research seminars. Trainees will present their research at national scientific meetings, publish several manuscripts in peer-reviewed journals, and begin to seek extramural grant support during their second year. The research opportunities in areas funded by NIH at CHORI include: (1) clinical research in sickle cell anemia and thalassemia, (2) red cell membrane structure and function, (3) immunologic development and immune response to vaccines, (4) bioiron, molecular regulation of ferritin synthesis, and iron toxicity, (5) lipid mediated signal transduction in stem cell biology, (6) genetic polymorphisms contributing to disease severity, (7) cord blood stem cell biology, and (8) stem cell transplantation for patients with hemoglobinopathies. Upon completion, trainees will be prepared to continue to work in an academic setting in the field of hemoglobinopathies and become qualified, independent scientists.