Integrated Wireless Tracking and Dosimetry for Radiation Oncology

描述(由申请人提供)：本提案寻求为NIH/NIBIB探索/发展研究资助计划下的R21拨款，以开发一种用于无线肿瘤跟踪和原位辐射剂量测量的新型集成微型应答器。这种微型设备将是放射肿瘤学中用于实时接收剂量测量和肿瘤运动管理的无价工具。建议的设备的主要设想应用是：(1)胸部和腹部肿瘤的立体定向全身放射治疗(SBRT)，以及(2)前列腺癌的高剂量放射(HDR)治疗。对于SBRT应用，应答器将被植入肿瘤组织及其附近，以在治疗时有效地监测剂量传递和组织跟踪。对于HDR前列腺癌的治疗，熟练的应用需要将该装置放置在通过尿路的导管中，以监测植入期间沿着放射敏感的膜管的剂量，或者放置在直肠内的球囊上的导管(球囊用于更好地固定靶点和更有利的直肠壁内的剂量分布)。对于辐射剂量测量，我们将探索一种基于绝缘金属(MOS)结构中与辐射产生负电荷相关的耗尽电容变化的器件结构和检测方案。为了实时监测肿瘤的位置，我们将使用一种具有优越的信噪比性能和增强的询问范围的磁跟踪方法。这两种器件将集成在相同的硅衬底上，并通过电感耦合链路(不需要电池)接收电力，从而简化了封装和封装。用于放射肿瘤学的集成无线跟踪和剂量测量这是针对NIH/NIBIB探索/开发研究资助计划而提交的R21修订申请，该计划旨在开发一种用于无线肿瘤跟踪和原位辐射剂量测量的新型集成微应答器。尽管审查是积极的(得分225)，但小组提出了一些关切，我们在本重新提交的材料中处理了这些关切。我们为回应审查而添加或更改的段落使用了不同的字体(Palatino Linux排版)。

DESCRIPTION (provided by applicant): This proposal seeks funding for an R21 grant under the NIH/NIBIB Exploratory/Developmental Research Grant Program to develop a novel integrated micro-transponder for wireless tumor tracking and in-situ radiation dosimetry. This microdevice will be an invaluable tool in radiation oncology for real-time received dosage measurements and tumor motion management. The primary envisioned application of the proposed device is for (1) Stereotactic Body Radiation Therapy (SBRT) treatments of thoracic and abdominal tumors and for (2) High Dose Radiation (HDR) treatment of prostate cancer. For SBRT applications transponders will be implanted in the tumor tissue and its vicinity for effective monitoring of dose delivery and tissue tracking at treatment. For HDR prostate cancer treatment the proficient application of the device would require its placement in the catheter passing through urethra to monitor dose along the radiosensitive membranous tube during implant or in the catheter attached to the balloon placed inside the rectum (balloon being utilized for better immobilization of the target and more favorable dose distribution in the rectum wall). For the radiation dose measurement, we will explore a device structure and detection scheme based on the depletion capacitance change associated with radiation-generated negative charge in the hafnium oxide gate of a metal-on-insulator (MOS) structure. In order to monitor tumor location in real-time, we will use a magnetic tracking method with superior signal- to-noise performance and enhanced interrogation range. Both of these devices will be integrated on the same silicon substrate and receive power from an inductively coupled link (no battery required), hence simplifying the packaging and encapsulation. Integrated Wireless Tracking and Dosimetry for Radiation Oncology This is a revised R21 application submitted in response to the NIH/NIBIB Exploratory/Developmental Research Grant Program to develop a novel integrated micro-transponder for wireless tumor tracking and in-situ radiation dosimetry. Although the reviews were positive (score 225), several concerns were raised by the panel which we have addressed in the present re-submission. The paragraphs that we have added or changed in response to the review use a different font (Palatino Linotype).