Validation of regional ventilation & perfusion and PA02 with a gold standard

描述(由申请人提供)：在正常肺中，肺通气量(VA)和灌注量(Q)密切匹配，以优化气体交换效率。不同的疾病状态会改变这种正常关系，并导致不同的VA/Q比率不匹配。局部VA/Q和局部氧分压的评估和量化对于各种肺部疾病的诊断、评估和治疗至关重要。最近，超极化气体磁共振方法已被开发用于研究换气和/或血流异常。获得了肺功能参数的区域图，并研究了生理性缺陷对这些参数的影响。新开发的超极化气体磁共振技术克服了与传统放射诊断工具相关的许多困难，并有望全面和准确地确定局部肺功能。最近，通过这种MRI技术获得的VA/Q数据被与核医学进行了比较。然而，这种方法的最终临床应用需要在较小范围内对照黄金标准进行仔细的验证。因此，本建议的主要目的是验证超极化气体磁共振技术在局部尺度上生成区域通风/灌流比图和肺泡氧分压图的有效性。我们假设这些图准确地反映了吸入和注射微球同时测量通气量和灌注量所获得的值。为了达到上述目标，我们将使用MRI技术和微球技术在一个健康的兔模型上获得VA/Q和PaO2的MAP。关键词：极化气体磁共振；区域通风；区域灌注；大脑皮层动脉血氧分压

DESCRIPTION (provided by applicant): In a normal lung pulmonary ventilation (VA) and perfusion (Q) are closely matched to optimize the gas exchange efficiency. Various disease states can alter this normal relationship and cause a heterogeneous VA/Q ratio mismatch. The assessment and quantification of regional VA/Q and regional oxygen partial pressure are of paramount importance to the diagnosis, evaluation, and treatment of a variety of pulmonary disorders. Recently, hyperpolarized gas MRI methods have been developed to study ventilation and/or perfusion abnormalities. Regional maps of functional lung parameters were acquired and the changes in these parameters caused by physiologic defects were investigated. The newly developed hyperpolarized gas MRI techniques overcome many of the difficulties associated with traditional radiological diagnostic tools and promises the comprehensive and accurate determination of regional lung function. Recently, VA/Q data obtained by this MRI technique has been compared to nuclear medicine. However, ultimate clinical use of this method demands a careful validation against a gold standard on a smaller scale. Therefore, the main goal of this proposal is to validate the hyperpolarized gas MRI technique for the generation of maps of the regional ventilation/perfusion ratios and maps of the alveolar partial pressure of oxygen on a local scale. We hypothesize that these maps accurately reflect the values obtained from simultaneous measurements of ventilation and perfusion with inhaled and injected microspheres. To achieve the stated goal, maps of VA/Q and PAO2 will be acquired using the MRI technique as well as the microsphere technique in a healthy rabbit model. Key Words: Polarized Gas MRI; Regional Ventilation; Regional Perfusion; Pegional PAO2