Nucleophilic amination with an azanide surrogate

本项目的目的是通过开发一种与自由基亲核取代链机制相容的易于处理的氮杂替代试剂来开发一种无过渡金属的亲核胺化方法。为了实现这一目标，我们必须设计一个最佳的氮代试剂，并确定“什么性质和条件是必不可少的实验反应性能？为了最大限度地发挥开发试剂的作用，我们必须确定“哪些亲电试剂与该试剂相容？这种方法的局限性是什么？最后，通过进行工业案例研究，我们将提出这样的问题：“这种方法与现有的工业流程相比如何？“，“我们可以以更可持续的方式生产哪些药物？“该项目将主要寻求建立概念的实验证明，并存在于EPSRC的两个研究主题中：'制造未来'和'物理科学'。在这些主题中，这项工作与EPSRC的两个主要研究领域有关：“合成有机化学”和“化学反应动力学和机理”。

The aim of this project is to develop a transition-metal-free approach to nucleophilic amination by developing an easily handled azanide surrogate reagent compatible with the radical-nucleophilic substitution chain mechanism. To realise this aim, we must design an optimal azanide surrogate reagent and determine "what properties and conditions are essential for experimental reaction performance?".To maximise the impact of the developed reagent, we must ascertain "which electrophiles are compatible with this reagent?", "What are the limitations of this approach?".Finally, by performing industrial case studies we will question "how does this approach compare with established industrial processes?", "What medicines can we manufacture in a more sustainable fashion?".This project will primarily seek to establish experimental proof of concept and lies in two EPSRC research themes: 'Manufacturing the future' and 'Physical sciences'. Within these themes, this work is relevant to two major EPSRC research areas: 'Synthetic Organic Chemistry' and 'Chemical Reaction Dynamics and Mechanisms'.