Center on Intersystem Regulation Drugs of Abuse

描述（由申请人提供）： 为了实现NIDA PSOCenter的目标，我们要求对现有的5个核心（行政，动物，生化药理学，细胞和免疫学，综合药理学和分子生物学）进行为期5年的竞争性更新，并增加一个新的核心，即分析核心。 该中心提高了生产力，协同作用和跨学科研究，并使新的教师招聘到滥用药物领域。 主要的综合主题包括：1）研究滥用药物及其内源性配体，特别是阿片类和大麻素，在调节疼痛，体温和免疫系统中的作用;研究提出并比较了由急性和慢性给药引起的这些系统变化的基本机制，和2）药物相互作用-因为个体很少滥用单一药物，重要的是要确定阿片类药物、可卡因和大麻等滥用药物之间是否发生相互作用，并评估不同系统中的相互作用类型是否相似。 实验结果是建立在不断发展的药物相互作用的理论。 该中心正在进行的项目的范围结合了体内和体外方法，在细胞，生物化学，分子和整个生物体水平上研究药物的影响。从行为测量到基因激活的信息整合刺激了合作，导致新的假设和结果。 P30中心的核心促进了多学科的相互作用，从而实现了真正的智力整合，从而建立了以前从未设想过的假设和实施实验路线。 虽然NIDA P30中心的重点是基础研究，但临床教师对药物滥用领域的转化研究潜力感兴趣。 坦普尔大学已作出重大承诺，将在未来的药物滥用研究领域保持增长。 核心小组正在提供技术专门知识，以具有成本效益的方式促进这一过渡。 P30中心是粘合剂，将其他人聚集在一起，吸引他们加入我们的杰出科学家团队。 该中心的工作使我们在药物相互作用和神经免疫药理学领域具有全国知名度。

DESCRIPTION (provided by applicant): In order to carry out the aims of the NIDA PSOCenter, we are requesting a 5-year competing renewal with support for the 5 current Cores (Administrative, Animal, Biochemical Pharmacology, Cell and Immunology, Integrative Pharmacology, and Molecular Biology) and the addition of a new Core, the Analytical Core. The Center has enhanced productivity, synergy, and interdisciplinary research, and enabled recruitment of new faculty into the field of drugs of abuse. Major integrative themes include 1) Study of drugs of abuse and their endogenous ligands, particularly opioids and cannabinoids, in regulation of pain, body temperature, and the immune system; research addresses and compares basic mechanisms responsible for changes in these systems produced by both acute and chronic administration, and 2) Drug interactions-as individuals rarely abuse a single drug, it is important to determine whether interactions occur among abused drugs such as opioids, cocaine, and marijuana, and to assess if the types of interactions are similar in the different systems. Experimental results are built on evolving theories of drug interactions. The scope of the ongoing projects in the Center marries in vivo and in vitro approaches that examine effects of drugs at the cellular, biochemical, molecular and whole-organism levels. Integration of information ranging from measurements of behavior to gene activation has stimulated collaborations leading to novel hypotheses and results. The Cores of the P30 Center have fostered multidisciplinary interactions resulting in a true intellectual integration leading to hypothesis building and implementation of lines of experimentation never previously conceived. While the focus of the NIDA P30 Center is basic research, clinical faculty have become interested in the potential for translational research in the area of drug abuse. Temple University has made major commitments that will sustain growth in the area of drug abuse research in the future. The Cores are providing the technical expertise to facilitate this transition in a cost-efficient way. The P30 Center is the glue that holds together and attracts others to our group of outstanding scientists. Work fostered by the Center has given us national visibility in the areas of drug interactions and neuroimmunopharmacology.