Irradiation

在过去提交的文件中，NCCC辐照共享资源的主要功能是为各种实验条件提供电离辐射，包括细胞辐照、整个动物（免疫抑制）和啮齿动物肿瘤治疗。虽然这些服务仍在继续，但新的重点是向达特茅斯研究界提供诊断和成像技术以及最先进的放射治疗计划能力。具体而言，我们增加了KeV/正电压X射线，MeV线性加速器和高剂量率（1921 r）治疗辐照能力的使用。顾问人员在使用激光治疗（如光动力疗法）方面也有丰富的经验和专业知识。关于基于研究的成像应用，我们增加了专用的 数字荧光透视、计算机断层扫描、诊断超声和体内荧光成像。这些增加的内容大大扩大了辐照共享资源的重点。增加的技术将对NCCC研究界大有裨益，特别是在临床前和基于动物的转化研究方面。

In past submissions the NCCC Irradiation Shared Resource has had the primary function of providing ionizing radiation for a variety of experimental conditions, including the irradiation of cells, whole animals (immunosuppression), and treatment of rodent tumors. Although these services continue, there is new emphasis on providing diagnostic and imaging technology and state-of-the-art radiation treatment planning capabilities to the Dartmouth research community. Specifically, we have added the use of KeV/orthovoltage x-ray, MeV linear accelerator and high-dose-rate (1921r) treatment irradiation capabilities. The Resource personnel also have significant experience and expertise in the use of laser-based treatments such as photodynamic therapy (PDT). Concerning research-based imaging applications, we have added dedicated digital fluoroscopy, computed tomography, diagnostic ultrasound, and in vivo fluorescent imaging. These additions have significantly broadened the focus of the Irradiation Shared Resource. The added technology will be of great benefit to the NCCC research community, especially in terms of preclinical and animal-based translational research.