IMMEDIATE EARLY GENE REGULATED DEVELOPMENT/PLASTICITY

描述（由申请人提供）：这是独立科学家奖授予Warren G. Tourtellotte, m.d.，博士。他目前是西北大学Feinberg医学院病理学、神经病学和神经科学助理教授。Tourtellotte博士将超过75%的专业精力用于研究中枢和周围神经系统发育相关基因的转录调节。这项研究职业奖将保证Tourtellotte博士稳定的薪水支持，使他能够将75%的专业精力投入到研究中。该机构支持75%的研究工作，这可以通过最小化临床服务承诺和最近扩大Tourtellotte博士可用的研究空间来证明。职业发展计划将扩展实验室中Egr转录因子功能的重点，包括细胞生理学，信号转导和全基因组调节网络分析的研究。Tourtellotte博士将利用职业发展资源加强机构内部和外部的合作网络，通过改进方法、科学人员和实验室可用的专业知识来加强研究计划。本研究计划将描述Egr转录因子在交感神经系统发育、神经营养因子介导的基因调控和信号转导中的作用。计划中的职业发展活动将充分利用西北大学丰富的协作和职业发展资源。

DESCRIPTION (provided by applicant): This is an Independent Scientist Award for Warren G. Tourtellotte, M.D., Ph.D. who is currently an Assistant Professor of Pathology, Neurology and Neuroscience at Northwestern University, Feinberg School of Medicine. Dr. Tourtellotte devotes greater than 75% professional effort to research focused on transcriptional regulation of genes involved in central and peripheral nervous system development. This Research Career Award will assure Dr. Tourtellotte stable salary support to allow him to commit 75% professional effort to research. The institution is supportive of a 75% research effort as evidenced by minimized clinical service commitments and recent expansion of the research space available to Dr. Tourtellotte. The career development plan will extend the focus of Egr transcription factor function in the laboratory to include studies of cellular physiology, signal transduction and genome wide regulatory network analysis. Dr. Tourtellotte will use the career development resources to strengthen collaborative networks both within the institution and externally to strengthen the research program by improving the methodology, scientific staff and expertise available to the laboratory. The Research Plan will characterize the role of Egr transcription factors in sympathetic nervous system development, neurotrophin mediated gene regulation and signal transduction. The planned career development activities will take full advantage of the rich collaborative and career development resources available at Northwestern University.