Heparin vs Lepirudin in Preventing Withdrawal Occulusion

中心静脉导管对于需要长期静脉通路的患者的护理是必不可少的，但凝块通常在导管尖端形成并阻塞血液抽取。虽然肝素冲洗通常用于防止这种情况，但几乎没有证据表明它们比盐水更有效。本研究比较了标准肝素与新抗凝剂来匹卢定冲洗的有效性，来匹卢定在导管插入后的前3 - 4周内至少每天给药。测量参数是导管发生撤回闭塞的频率。 本研究已累积51例患者，由于我们的基本研究护士已离开我们的部门且未被替换，因此即将终止。最后一个病人刚刚完成了观察期。一旦她的图表被审查导管撤回闭塞的发生率，该研究将被揭盲，以确定它是否有足够的把握度来证明效果之间的显著差异

Central venous catheters are essential for the care of patients requiring chronic venous access, yet clots often develop at the catheter tip and block blood withdrawal. Although heparin flushes are routinely used to prevent this, their is little evidence that they are any more effective than saline. This study compares the effectiveness of standard heparin with flushes of a new anticoagulant, lepirudin, given at least daily for the first 3 - 4 weeks after the catheter has been inserted. The measured parameter is the frequency with which the catheters develop withdrawal occlusion. Fifty-one patients have been accrued on this study, which is about to be terminated because our essential research nurse has left our department and is not being replaced. The last patient accrued has just completed her period of observation. Once her chart is reviewed for incidences of catheter withdrawal occlusion, the study will be unblinded to determine whether it had sufficient power to demonstrate significant differences between the effect