Annual Meeting of the Mutant Mouse Regional Resource Centers

描述（由申请人提供）：突变小鼠区域资源中心（MMRRC）现在是在其第七年的运作（www.mmrrc.org）。我们已经拥有超过1，300种突变和基因工程小鼠品系作为冷冻保存的种质或活菌落，以及超过27，000种小鼠品系作为胚胎干细胞（ESC）。 总共超过28，300行。我们现在是世界上最大的用于生物医学研究的小鼠库。MMRRC由三个机构组成：（1）加利福尼亚大学戴维斯分校，（2）北卡罗来纳州大学 查佩尔山，和（3）密苏里州大学。此外，杰克逊实验室还充当信息和客户服务中心（ICSC）。MMRRCs的多机构协作性质需要执行站点之间的频繁沟通。有许多业务问题必须解决，特别是随着进出口小鼠数量呈指数级增长。该提案要求提供资金，以支持MMRRC第七届年度会议。本次会议的目的是汇集：（1）主要研究者和其他关键个人从四个MMRRC网站和ICSC，（2）NCRR和其他NIH计划的工作人员，和（3）其他成员的科学界与突变小鼠资源的利益，讨论共同的问题和问题，并分享想法和潜在的解决方案有关的MMRRC的持续功能。这次MMRRC年会的价值怎么强调都不为过。虽然在其第七个年头，MMRRC仍然是一个相对较新的计划。它的多机构组成和协作性质决定了所有执行站点和NIH之间的沟通至关重要，特别是因为这是一个U42机制。拟议的会议将促进MMRRC的持续成功和发展，使每个中心和NIH计划的个人能够会面，讨论和解决与MMRRC运作相关的计划，政策和技术问题。 该提案要求提供资金，以支持MMRRC第七届年度会议。本次会议的目的是汇集：（1）主要研究者和其他关键个人从三个MMRRC网站和ICSC，（2）NCRR和其他NIH计划的工作人员，和（3）其他成员的科学界与突变小鼠资源的利益，讨论共同的问题和问题，并分享想法和潜在的解决方案有关的MMRRC的持续功能。

DESCRIPTION (provided by applicant): The Mutant Mouse Regional Resource Centers (MMRRC) are now in their 7th year of operation (www.mmrrc.org). We have grown to have an inventory of over 1,300 mutant and genetically engineered mouse lines as cryopreserved germplasm or live colonies, as well as over 27,000 mouse lines as embryonic stem cells (ESCs) for a total of over 28,300 lines. We are now the largest repository of mice for biomedical research in the world. The MMRRC is comprised of three (3) institutional components: (1) the University of California-Davis, (2) the University of North Carolina Chapel Hill, and (3) the University of Missouri. In addition, Jackson Laboratory serves as an information and customer service center (ICSC). The multi-institutional, collaborative nature of the MMRRCs necessitates frequent communication among performing sites. There are numerous operational issues that must be addressed, especially as the volume of imported and exported mice coming is increasing exponentially. This proposal requests funds to support the 7th Annual MMRRC Meeting. The objective of this meeting is to bring together: (1) the Principal Investigators and other key individuals from each of the four MMRRC sites and the ICSC, (2) NCRR and other NIH Program staff, and (3) other members of the scientific community with interests in mutant mouse resources, to discuss common issues and problems and to share ideas and potential solutions related to the ongoing functions of the MMRRC. The value of this Annual Meeting of the MMRRC cannot be emphasized enough. While in its seventh year, the MMRRC is still a relatively new program. It's multi-institutional composition and collaborative nature dictates that communication among all performing sites and the NIH is critical, especially as this is a U42 mechanism. The proposed conference will facilitate the continued success and growth of the MMRRC by enabling individuals from each Center and NIH program to meet, discuss and resolve programmatic, policy and technical issues associated with the operation of the MMRRCs. This proposal requests funds to support the 7th Annual MMRRC Meeting. The objective of this meeting is to bring together: (1) the Principal Investigators and other key individuals from each of the three MMRRC sites and the ICSC, (2) NCRR and other NIH Program staff, and (3) other members of the scientific community with interests in mutant mouse resources, to discuss common issues and problems and to share ideas and potential solutions related to the ongoing functions of the MMRRC.