Contingent Tolerance to Cocaine in Pigeons

描述(由申请人提供)：先前关于可卡因对大鼠和猴子手术行为影响的耐受性的研究表明，耐受性取决于服药前或服药后。最近发表的一项鸽子实验，初步研究没有发现耐受性同样取决于何时给药。这项拟议的研究将通过三个实验进一步研究行为因素和药理学因素在鸽子对可卡因耐受性发展中的作用。实验1将考察在可卡因作用下进食对可卡因耐受性的发展在之前的操作行为阶段中的贡献。实验2将检验单纯药物暴露而不暴露于行为会话在行为会话期间对可卡因耐受性的影响。实验3将考察急性和慢性可卡因给药对可卡因药代动力学的影响。这项研究项目将考察行为因素，包括实验阶段和进食，以及药物因素在鸽子对可卡因行为影响的耐受性发展中的作用。

DESCRIPTION (provided by applicant): Previous research on tolerance to effects of cocaine on operant behavior in rats and monkeys has revealed tolerance contingent on whether the drug is given pre or post session. A recently published experiment with pigeons, and the preliminary study did not find that tolerance was similarly contingent on when the drug was administered. The proposed research will further examine the role of behavioral factors and pharmacological factors in the development of tolerance to cocaine in pigeons through three experiments. Experiment 1 will examine the contributions of eating while under the effects of cocaine to the development of tolerance to cocaine during a preceding operant behavioral session. Experiment 2 will examine effects of mere drug exposure without exposure to a behavioral session in the development of tolerance to cocaine during a behavioral session. Experiment 3 will examine effects of acute and chronic cocaine administration on the pharmacokinetics of cocaine. This program of research will examine the role of behavioral factors, including the experimental session and eating, and pharmacological factors in the development of tolerance to behavioral effects of cocaine in pigeons.