The roles of the COXs in normal physiology and in pathol

这些研究的主要目的是利用COX缺陷小鼠阐明COX-1和COX-2在正常生理和各种病理状态下的个体作用。这些研究包括COX亚型在胃溃疡、肺部炎症、血管发育和血压调节中的作用。此外，实验室的工作重点是使用COX-1和COX-2缺陷小鼠ES细胞来研究COX-1和COX-2在内皮细胞发育和血管生成中的作用。研究表明，缺乏COX-1或COX-2均不能抑制小鼠体外胚胎干细胞向内皮样细胞的分化。然而，COX-1和COX-2选择性抑制剂的研究表明，COX-2抑制剂通过COX独立的机制抑制内皮样细胞的发育。

The major goals of these studies are to elucidate the individual roles of COX-1 and COX-2 in normal physiology and in various pathological states using the COX deficient mice. Included in these studies are the roles of the COX isoforms in gastric ulceration, lung inflammation, vascular development and blood pressure regulation. Additionally, effort within the laboratory has focused on using COX-1 and COX-2 deficient mouse ES cells to study the roles of COX-1 and COX-2 in endothelial cell development and angiogenesis. Studies suggest that neither the deficiency of COX-1 or COX-2 inhibited mouse ES cell differentiation into endothelial-like cells in vitro. Whereas studies with COX-1 and COX-2 selective inhibitors have indicated that the COX-2 inhibitors inhibits endothelial-like cell development by a COX independent mechanism.