AGING, STRESS, OBESITY AND CHRONIC INFLAMMATION

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 65岁以上的人是我们人口中增长最快的群体。关节炎、癌症、糖尿病、心血管疾病和痴呆是构成这些衰老疾病的最大组成部分的疾病。在这些疾病的发病机制中起主要作用的两个因素是心理社会因素和慢性炎症。压力、社会经济地位、抑郁、孤独、悲观和许多不良健康行为是与这些疾病的病因和促进有关的一些心理社会因素。慢性炎症在这些疾病中的重要性从关节炎和心血管文献中的大量报告中获得了可信度。另一个与慢性炎症相关的国家健康问题是肥胖，这是所有衰老疾病的危险因素。 在这个建议中，我们将评估IL-6和一组额外的生物心理社会和基因组因素，这些因素已被证明或假设与炎症级联反应有关。我们将探讨低SES压力和慢性炎症之间的关联。 此外，我们还将评估其他可能改变或混淆这种效应的生物心理社会因素。 这项试点研究将包括评估一组（n=60）35-60岁的超重男性或女性的低（每年15 - 30，000美元）和高（每年50 - 80，000美元）的社会经济地位，超过1个月，评估各种基因组和生物心理社会因素相关的慢性炎症。将分别使用静脉穿刺和唾液技术获取血清和唾液样本。在初始研究访视后4周内，将在两组受试者中评价弹性（从日常压力源中恢复的能力）与炎症反应的关系，如通过每日日记方法确定的。每周一次的皮质醇分泌评估将增加一个生物应激措施，这一评估。CRP和IL-6将在每月日志评估的第二周末和月底进行。在这个月之前和月底，我们将获得一组与慢性炎症相关的额外生物标志物，并将它们与低SES受试者在这个月内的压力和弹性相关联。对于高SES组，将要求患者返回进行相同的评估，但我们不会要求他们使用日记。我们对低SES组的弹性变化特别感兴趣，这些患者的日记数据将有助于设计针对他们的干预措施。 将在基线时进行单次腹部CT扫描，以提供内脏脂肪含量的信息。一部分人还将接受MRI检查，以获得有关所有体脂沉积的信息。 预计这项研究将产生初步的数据和支持的R-21和计划项目提交的压力，衰老和慢性炎症的国家老龄化研究所。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. People over 65 represent the fastest growing segment in our population. Arthritis, cancer, diabetes, cardiovascular disease, and dementia are diseases that make up the largest component of these diseases of aging. Two elements that appear to play a major role in the pathogenesis of these disorders are psychosocial factors and chronic inflammation. Stress, socioeconomic status, depression, loneliness, pessimism, and numerous poor health behaviors are a few of the psychosocial factors that have been implicated in the etiology and promotion of these disorders. The importance of chronic inflammation in these disorders gains credibility from numerous reports in the arthritis and cardiovascular literature. Another national health problem associated with chronic inflammation is obesity which is a risk factor for all of the diseases of aging.. In this proposal we will be evaluating IL-6 and an additional set of biopsychosocial and genomic factors that have been demonstrated or postulated to be linked to the inflammatory cascade. We will explore the association between the stress of low SES and chronic inflammation. Additionally, we will evaluate other biopsychosocial factors that may modify or confound this effect. This pilot study will consist of evaluating a cohort (n=60) of 35-60 year old overweight males or females of low ($15-30,000 per annum) and high ($50-80,000 per annum) socioeconomic status, over 1 month, assessing various genomic and biopsychosocial factors related to chronic inflammation. Venipuncture and salivette techniques will be used to obtain serum and saliva samples, respectively. During the 4 weeks after the initial study visit, the relationship of resiliency (ability to recover from daily stressors), as determined by daily diary methods, to the inflammatory response will be evaluated on the subjects in the both grouped. Weekly assessments of cortisol secretion will add a biologic stress measure to this evaluation. CRP and IL-6 will be drawn at the end of the second week of the monthly diary assessment and at the end of the month. Before and at the end of the month we will acquire an additional battery of biomarkers associated with chronic inflammation and correlate them with the low SES subjects' stress and resilience during the month. For the high SES group, patients will be asked to return for the same assessment, but we will not ask them to use the diaries. We are particularly interested in the variation in resiliency in the low SES group, and the diary data from these patients will be helpful in designing an intervention specific to them. A single cut abdominal CT scan will be obtained at baseline to provide information on visceral fat content. A subset of individuals will also receive an MRI to obtain information on all body fat deposits. It is anticipated that this study will yield preliminary data and support for an R-21 and Program Project submission on Stress, Aging and Chronic Inflammation to the National Institute of Aging.