REGULATION OF HEPATIC INSULIN EXTRACTION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们将非常详细地研究与胰岛素抵抗相比，β细胞功能/功能障碍的作用。在2号和15号染色体上已经确定了与2型糖尿病相关的遗传基因。我们将研究具有和不具有这些已知糖尿病易感基因座的个体的β细胞功能/功能障碍和胰岛素抵抗。随着未来发现更多的基因座，我们将能够将这些基因座包括在我们的分析中，以确定不同的糖尿病易感基因对胰岛素分泌和胰岛素作用的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We will be looking in great detail at the roles of beta cell function/dysfunction, in comparison with insulin resistance. Genetic loci linked to type 2 diabetes have been identified on chromosomes 2 and 15. We will be looking at beta cell function/dysfunction and insulin resistance in individuals with and without these known diabetes susceptibility loci. As additional loci are identified in the future, we will be able to include these loci in our analyses to define the effects of different diabetes susceptibility genes on insulin secretion and insulin action.