WEIGHT LOSS AND EXERCISE IN OBESE ELDERLY

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 肥胖会导致严重的并发症，并损害生活质量。 此外，在老年人中，肥胖可通过加剧与衰老和缺乏身体活动相关的力量、耐力、平衡和流动性的下降而导致虚弱。 老年人肥胖的适当治疗是有争议的，因为随着老年人体重指数的增加，相对健康风险降低，减肥对骨骼健康和肌肉质量的潜在有害影响。 这项研究的主要目的是评估减肥和运动对身体功能、身体成分、骨骼和肌肉代谢以及体弱肥胖老年男性和女性生活质量的独立和综合影响。 中心假设是，在虚弱的肥胖受试者中，体重减轻将改善身体功能和生活质量，而运动的增加不仅会增加这些结果的改善，而且会减轻体重减轻对骨骼和肌肉质量的不良影响。 为了检验这一假设，将100名身体虚弱的老年（65-85岁）肥胖男性和女性（BMI > kg/m2）随机分为4个治疗组：1）对照组，2）10%体重减轻组，3）运动训练组，以及4）10%体重减轻加运动训练组。 身体功能测量（体能测试，基于体能的力量、柔韧性、耐力、平衡和运动控制测试，以及评估功能状态的问卷），身体成分（通过双能X线吸收测定法评估全身脂肪和去脂肪质量，通过磁共振成像测量腹部脂肪和大腿肌肉质量），骨矿物质密度（BMD）和骨转换（全身和局部BMD与骨形成和吸收的标志物结合），使用稳定同位素示踪技术的肌蛋白合成肌原纤维蛋白合成率），在52周治疗干预之前、期间和之后，将确定与健康相关的生活质量（简明健康调查表和体重对生活质量的影响问卷）。 被随机分配到减肥组和减肥加运动组的受试者将参加华盛顿大学体重管理中心的综合体重管理项目。 随机分配至运动组或减肥加运动组的受试者将参加一项监督运动训练计划（90分钟，每周3天，持续52周）。 一项为期一年的试点研究的结果令人鼓舞，表明生活方式改变计划对改善体弱肥胖老年受试者的身体功能的可行性和有效性。 这项随机对照试验产生的数据将最终为越来越多的虚弱肥胖老年男性和女性建立适当的治疗指南。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Obesity causes serious medical complications and impairs quality of life. Moreover, in elderly persons, obesity can lead to frailty by exacerbating the decline in strength, endurance, balance and mobility associated with aging and physical inactivity. Appropriate treatment for obesity in elderly persons is controversial because of the decreased relative health risks with increasing body mass index in the elderly and the potential harmful effects of weightloss on bone health and muscle mass. The primary objectives of the proposed research are to evaluate the independent and combined effects of weight loss and exercise on physical function, body composition, bone and muscle metabolism, and quality of life in frail, obese elderly men and women. The central hypothesis is that in frail obese subjects, weight loss will improve physical function and quality of life, while the addition of exercise will not only augment improvement in these outcomes, but also attenuate the adverse effects of weight loss on bone and muscle masses. To test this hypothesis, 100 elderly (65-85 years old) obese men and women (BMI > kg/m2) with physical fraility will be randomized to 4 treatment groups: 1)control, 2) 10% weight loss, 3) exercise training, and 4) 10% weight loss plus exercise training. Measures of physical function (physical performance test, performance-based tests of strength, flexibility, endurance, balance, and motor control, and questionnaires that evaluate functional status), body composition (total body fat and fat-free mass evaluated by dual energy x-ray absorptiometry, abdominal fat and thigh muscle mass measured by magnetic resonance imaging), bone mineral density (BMD) and bone turnover (total body and regional BMD in conjunction with markers of bone formation and resorption), muscle protein synthesis myofibrillar protein synthesis rate using stabe isotope tracer techniques), and health related quality-of-life (Short-Form Health Survey and Impact of Weight on Quality of Life questionnaires) will be determined before, during, and after a 52-week treatment intervention. Subjects randomized to weight loss and weight loss plus exercise group will participate in a comprehensive weight management program at the Washington University Weight Management Center. Subjects randomized to exercie or weight loss plus exercise will participate in a supervised exercise-training program (90-min sessions, 3 days/week for 52 weeks). Encouraging results from a 1-year pilot study suggest the feasibility and efficacy of a lifestyle modification program towards improving physical function in frail obese elderly subjects. The data generated from this proposed randomized controlled trial will ultimately establish appropriate treatment guidelines for the increasing number of frail obese elderly men and women.