EFFECT OF SYSTEMIC LUPUS ERYTHMATOSUS IN MINORITIES

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究旨在探讨系统性红斑狼疮（SLE）患者的病程和早期预后与人口统计学、社会经济学和遗传因素之间的相互关系。本研究在休斯顿和加尔维斯顿，德克萨斯州以及波多黎各设有研究中心，除了随访非裔美国人和白人SLE患者外，还随访了2个不同地点的西班牙裔患者：德克萨斯州和波多黎各。 LUMINA研究的另一个维度是PROFILE子研究。PROFILE是UAB SLE遗传学PO 1项目的项目4。它的目标是确定遗传学在狼疮结果中所起的作用。因此，不仅获得患者DNA以研究与SLE相关的基因，还招募父母和兄弟姐妹（TRIO家族），以便也可以分析他们的DNA。 迄今为止的结果表明，西班牙裔和非洲裔美国人患者有更多的活动性SLE，在较早的发病年龄，和一个不太有利的社会经济人口结构（西班牙裔比非洲裔美国人更差），这使他们倾向于一个不太有利的自然史。[阿拉尔，1999年]

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this project is to study the inter-relationship between demographic, socioeconomic, and genetic factors in determining the course and early outcome in patients with systemic lupus erythematosus (SLE). This study has centers in Houston and Galveston, Texas as well in Puerto Rico, which in addition to following African-American and Caucasian patients with SLE, follows Hispanic patients at 2 different locations: Texas and Puerto Rico. An added dimension of the LUMINA study is the PROFILE sub-study. PROFILE is Project 4 of the PO1 Program Project in the genetics of SLE at UAB. Its goal is to determine the role that genetics plays in the outcome of lupus. As such, not only is patient DNA obtained to investigate genes related to SLE, but parents and siblings are being recruited (TRIO families) so that their DNA may be analyzed as well. Results to date indicate that Hispanic and African-American patients have more active SLE, at an earlier age of onset, and a less favorable socioeconomic-demographic structure (worse among Hispanics than African-American), which predispose them to a less favorable natural history. [Alarc¿n, 1999]