Enhancing the Vascularization Properties of Skin Tissue

描述(由申请人提供)：到目前为止，还没有专门针对慢性伤口的缺氧性质的生物治疗选择被开发和销售。虽然单独应用血管生成因子可以刺激某些方面的血管生成，但需要多个因子的同时表达才能促进形态和功能正常的血管。在这项第二阶段的研究中，我们建议对一种经过基因修饰的人角质形成细胞株进行表征，以协调表达多种治疗因子的升高水平。Stratech公司在体外对获得专利的人类角质形成细胞系进行基因工程的进展使其具有完成这项工作的独特地位。如果成功，拟议的研究最终将导致改进治疗方法的开发和商业化，以促进慢性伤口和其他严重皮肤缺陷的愈合。

DESCRIPTION (provided by applicant): To date no biological treatment options specifically targeting the hypoxic nature of chronic wounds have been developed and marketed. While administration of individual angiogenic factors may stimulate some aspects of angiogenesis, the simultaneous expression of multiple factors is required to promote morphologically and functionally normal vessels. In this Phase II study, we propose to characterize a human keratinocyte cell line genetically-modified to coordinately express elevated levels of multiple therapeutic factors. Advances in ex vivo genetic engineering of a patented human keratinocyte cell line at Stratatech Corporation has made it uniquely positioned to complete this work. If successful, the proposed research will ultimately lead to the development and commercialization of improved treatments to promote the healing of chronic wounds and other severe skin defects.