NMR SYSTEMS : 2 BRUKER AVANCE 500 CONSOLES

该子项目是利用由NIH/NCRR资助的共享仪器补助金提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是资助机构，不一定是研究者的机构。宾夕法尼亚大学化学系现有教职工17人，研究生和博士后158人，在合成有机与无机化学、生物有机与生物无机化学、生物化学和结构生物学等领域开展前沿研究。此外，宾夕法尼亚大学分子发现中心的合成核心（PCMD）是最近资助的10个NIH路线图国家筛选中心之一的主要组成部分，现在（2005年）设在化学系。这些程序都需要最先进的核磁共振仪器。为此，该应用程序的主要目的是将该部门快速老化的核磁共振基础设施恢复到最先进的水平。所要求的新的核磁共振仪器将对在该系进行的所有科学研究产生直接和持久的影响，并改善对常驻研究生和博士后的培训和教育。在过去的十年中，该部门已将联邦政府对研究的支持从910万美元增加到1400多万美元。与此同时，该部门在吸引同行评审资金方面一直名列全国前茅。此外，该部门还作出了7项杰出任命，包括2名高级和5名初级；完成了三项杰出的次要任命，包括一名NAS成员；有多名教师获得国家和国际奖项，包括三次获得美国科学院/美国化学学会会员资格、国家科学奖章和诺贝尔化学奖；提高研究生培养质量；开发新空间，改造旧空间，营造高质量的科研环境。然而，该部门的成功对研究基础设施产生了越来越大的需求，特别是在核磁共振仪器领域。相关性：拟议的最先进的核磁共振仪器将显著增强约17名高度活跃的有机、生物有机和生物教员的研究能力，指导158名研究生和博士后从事尖端研究，旨在通过减少疾病和提高美国和整个世界公民的福祉来改善公众健康。公共卫生研究领域包括癌症、传染病、阿尔茨海默病等神经退行性疾病以及心脏病和心血管疾病。

This subproject is one of many research subprojects utilizing the resources provided by a Shared Instrumentation Grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the grant, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): The Department of Chemistry at the University of Pennsylvania has 17 faculty directing 158 graduate students and post-doctoral fellows conducting frontier research in synthetic organic and inorganic chemistry, bioorganic and bioinorganic chemistry, biochemistry and structural biology. In addition, the Synthetic Core of the Penn Center for Molecular Discovery (PCMD), a major component of one of the 10 recently funded NIH Roadmap National Screening Centers, is now (2005) housed in the Chemistry Department. Each of these programs requires state of the art NMR instrumentation. Towards this end, the principal aim of this application is to restore the Department's rapidly aging NMR infrastructure to state of the art. The new NMR instrumentation requested will have an immediate and lasting impact on all science conducted in the Department, and improve the training and education of the resident graduate students and postdoctoral fellows. During the last ten years, the Department has increased the federal support for research from $9.1 million to over $14 million. Over the same time the Department has consistently ranked among the best in the Nation in attracting peer reviewed funding. In addition, the department has: made seven outstanding appointments, including two senior and five junior; made three outstanding secondary appointments, including a NAS member; had several of its faculty receive national and international awards including three NAS/FRS memberships, the National Medal of Science and the Nobel Prize in chemistry; increased the quality of graduate students; and developed new space and renovated older space to produce a high quality research environment. The success of the Department however has produced an increasing demand on the research infrastructure, especially in the area of NMR instrumentation. Relevance: The proposed state of the art NMR instrumentation will significantly augment the research capability of some 17 highly active organic, bioorganic and biological faculty members, directing 158 graduate students and postdoctoral fellows engaged in cutting edge research, directed towards improving the public health by reducing disease and enhancing the well being of the citizens of the United States and the world as a whole. The areas of public health research include, among others, cancer, infectious diseases, neurodegenerative diseases such as Alzheimer's disease, and heart and cardiovascular disease.