NMR systems : 2 Bruker Avance 500 Consoles

描述（由申请人提供）：宾夕法尼亚大学化学系有17名教师指导158名研究生和博士后研究员进行合成有机和无机化学，生物有机和生物无机化学，生物化学和结构生物学的前沿研究。此外，宾夕法尼亚大学分子发现中心（PCMD）的合成核心是最近资助的10个NIH路线图国家筛选中心之一的主要组成部分，现在（2005年）设在化学系。这些程序中的每一个都需要最先进的NMR仪器。为此，这项申请的主要目的是恢复该部门的迅速老化的核磁共振基础设施，以最先进的国家要求新的核磁共振仪器将有一个在该部门进行的所有科学的直接和持久的影响，并改善驻地研究生和博士后研究员的培训和教育。 在过去十年中，该部已将联邦对研究的支持从910万美元增加到1 400多万美元。与此同时，该部在吸引同行审查资金方面一直名列全国最佳之列。此外，该系还：作出了七项杰出的任命，包括两名高级和五名初级;作出了三项杰出的二级任命，包括一名NAS成员;有几名教师获得国家和国际奖项，包括三个NAS/FRS会员资格，国家科学奖章和诺贝尔化学奖;提高了研究生的质量;并开发新的空间和翻新旧的空间，以创造一个高质量的研究环境。然而，该部门的成功产生了对研究基础设施的需求越来越大，特别是在核磁共振仪器领域。 相关性：拟议的最先进的核磁共振仪器的状态将显着增强约17个高度活跃的有机，生物有机和生物教师的研究能力，指导158名研究生和博士后研究员从事前沿研究，旨在通过减少疾病和提高美国和世界公民的福祉来改善公众健康。公共卫生研究领域包括癌症、传染病、神经退行性疾病（如阿尔茨海默病）以及心脏和心血管疾病。

DESCRIPTION (provided by applicant): The Department of Chemistry at the University of Pennsylvania has 17 faculty directing 158 graduate students and post-doctoral fellows conducting frontier research in synthetic organic and inorganic chemistry, bioorganic and bioinorganic chemistry, biochemistry and structural biology. In addition, the Synthetic Core of the Penn Center for Molecular Discovery (PCMD), a major component of one of the 10 recently funded NIH Roadmap National Screening Centers, is now (2005) housed in the Chemistry Department. Each of these programs requires state of the art NMR instrumentation. Towards this end, the principal aim of this application is to restore the Department's rapidly aging NMR infrastructure to state of the art. The new NMR instrumentation requested will have an immediate and lasting impact on all science conducted in the Department, and improve the training and education of the resident graduate students and postdoctoral fellows. During the last ten years, the Department has increased the federal support for research from $9.1 million to over $14 million. Over the same time the Department has consistently ranked among the best in the Nation in attracting peer reviewed funding. In addition, the department has: made seven outstanding appointments, including two senior and five junior; made three outstanding secondary appointments, including a NAS member; had several of its faculty receive national and international awards including three NAS/FRS memberships, the National Medal of Science and the Nobel Prize in chemistry; increased the quality of graduate students; and developed new space and renovated older space to produce a high quality research environment. The success of the Department however has produced an increasing demand on the research infrastructure, especially in the area of NMR instrumentation. Relevance: The proposed state of the art NMR instrumentation will significantly augment the research capability of some 17 highly active organic, bioorganic and biological faculty members, directing 158 graduate students and postdoctoral fellows engaged in cutting edge research, directed towards improving the public health by reducing disease and enhancing the well being of the citizens of the United States and the world as a whole. The areas of public health research include, among others, cancer, infectious diseases, neurodegenerative diseases such as Alzheimer's disease, and heart and cardiovascular disease.