Bruker 800 MHz TCI CryoProbe

描述(由申请人提供)：为支持加州大学洛杉矶分校NIH、NSF和能源部资助的一组科学家的研究，申请800 MHz核磁共振低温探测仪，该探测仪将用于帮助解决主要用户建议研究的蛋白质、核酸、DNA-蛋白质、RNA-蛋白质和蛋白质-蛋白质复合体的结构和动力学。(1)蛋白质及其复合体的核磁共振研究(Clubb)，(2)核酸及其复合体的结构研究(Feigon)，(3)SAM结构域的结构与功能(Bowie)，(4)HIV-1 VPR和HHR23A相关细胞蛋白的结构/功能(Chen)，(5)XIs和Fis(Johnson)对噬菌体Lambda位点特异性DMA重组的调控，(6)生物分子核磁共振(LIN)中的混沌控制和敏感性增强(LIN)。探测器将位于加州大学洛杉矶分校-能源部核磁共振技术中心。它将显着提高该中心单台800兆赫光谱仪的灵敏度，使更多的项目能够受益于使用这台高场仪器。

DESCRIPTION (provided by applicant): Funding is requested for an 800 MHz NMR CryoProbe to support the research of a group of NIH, NSF and DOE funded scientists at UCLA, this probe will be used to help solve the structures and dynamics of proteins, nucleic acids, DNA-protein, RNA-protein, and protein-protein complexes proposed for investigation by the major users. The research projects of the six major users are described with the following titles: (1) NMR studies of proteins and their complexes (Clubb), (2) Structural studies of nucleic acids and complexes (Feigon), (3) SAM domain structure and function (Bowie), (4) Structure/function of HIV-1 Vpr and HHR23A associated cellular proteins (Chen), (5) Regulation of phage lambda site-specific DMA recombination by Xis and Fis (Johnson), and (6) Chaos Control and Sensitivity Enhancement in Biomolecular NMR (Lin). The probe will be located in the UCLA-DOE NMR Technology Center. It will significantly improve the sensitivity of the Center's single 800 MHz spectrometer enabling a greater number of projects to benefit from access to this high-field instrument.