HIV/STD Risk among Young Expectant Fathers: Relationship Attachment & Transition

描述（由申请人提供）：本补充的目的是探索两种可能的遗传影响，5-羟色胺转运蛋白（5-HTT）基因和多巴胺D4受体（DRD 4）基因，对年轻准父母的性风险行为和性病发病率。我们将在一个更大的生态框架内纳入生物影响，以评估遗传和生物因素如何与心理，社会和环境因素相互作用，以影响年轻夫妇的性风险和性病发病率。我们将在一项针对年轻准爸爸及其怀孕青少年伴侣的多中心纵向研究的子研究中探讨这些问题。这项子研究将评估432名男性和女性在康涅狄格州的健康诊所进行。将通过音频计算机辅助自我访谈（ACASI）、半年一次的STD检测和通过口腔拭子进行的基因检测收集数据。一对夫妇的成员将在三个时间点进行评估，无论关系状态如何：在怀孕的第三个月，产后6个月和产后12个月。本研究的目的是描述低社会经济地位，大多数少数民族的年轻夫妇过渡到父母的5-HTTLPR和DRD 4基因多态性的频率，并评估5-HTTLPR和DRD 4基因多态性之间的相互作用和二元，家庭和社区水平的心理社会因素对性风险行为和性病发病率。遗传和环境的相互作用已被证明在年轻人的其他危险行为中发挥重要作用。因此，在高风险人群中识别可能的遗传-环境相互作用可能有助于创建有针对性的干预措施，这些干预措施最成功地导致长期行为改变。该补充的目标是成为第一批研究之一，探索年轻异性恋夫妇中可能的遗传和心理社会相互作用对艾滋病毒/性病风险行为的影响，并利用这些结果设计更大的队列和干预研究，评估遗传-心理社会-行为相互作用。公共卫生相关性：这项研究将评估遗传和生物因素如何与心理，社会和环境因素相互作用，影响年轻夫妇的性风险和性病发病率。研究结果可用于提供信息和定制预防干预措施，以减少男子、妇女和夫妇中的艾滋病毒和性传播疾病。

DESCRIPTION (provided by applicant): The purpose of this supplement is to explore two possible genetic influences, the serotonin transporter (5-HTT) gene and the dopamine D4 receptor (DRD4) gene, on sexual risk behavior and STD incidence among young expectant parents. We will incorporate biological influences within a larger ecological framework to assess how genetic and biological factors interact with psychological, social, and environmental factors to influence sexual risk and STD incidence among young couples. We will examine these issues in a sub-study of a multi-site longitudinal study of young expectant fathers and their pregnant adolescent partners. The sub-study will assess 432 men and women to be conducted in health clinics in Connecticut. Data will be collected through Audio Computer Assisted Self-Interview (ACASI), semi-annual STD testing, and genetic testing through buccal swabs. Members of a couple will be assessed at three time points regardless of relationship status: during 3rd trimester of pregnancy, 6-months postpartum, and 12 months postpartum. The aims of the study are to describe the frequencies of 5-HTTLPR and DRD4 genetic polymorphisms among low-socioeconomic status, mostly minority young couples transitioning to parenthood, and to assess the interactions between 5-HTTLPR and DRD4 genetic polymorphisms and dyadic, family, and community-level psychosocial factors on sexual risk behavior and STD incidence. Genetic and environment interactions have been shown to play an important role in other risk behaviors among youth. Therefore, identifying possible genetic-environmental interactions in high- risk populations may aid in the creation of tailored interventions that have the best success to lead to long-term behavioral change. The goal of this supplement is to be one of the first studies to explore possible genetic and psychosocial interactions on HIV/STD risk behavior among young heterosexual couples and to use these results to design larger cohort and intervention studies that assess genetic-psychosocial-behavioral interactions. PUBLIC HEALTH RELEVANCE: This study will assess how genetic and biological factors interact with psychological, social, and environmental factors to influence sexual risk and STD incidence among young couples. Results can be used to inform and tailor prevention interventions aimed at reducing HIV and STDs among men, women, and couples.