Lipid-Based Nanocapsules and Nano Fusion Machines

当我们过渡到CCR纳米生物学计划时，我们正在计划和设计基于脂质的纳米胶囊和纳米融合机器的实验。我们相信，我们在阐明病毒进入机制方面的知识和技能将有助于找到新的抗癌药物递送方法。预期的项目包括设计和研究多功能脂质体携带药物（例如有毒或抗炎物质），与疾病特异性靶向剂（例如抗体）结合，并用成像剂标记。我们计划使用外部能源（X射线、光、微波、超声波）在最佳时间和有限体积内对脂质体进行受控破坏。脂质体将被聚合物或聚合脂质保护，并被修饰以允许受控的破坏。我们计划利用一类新的融合相关小跨膜（FAST）蛋白来构建纳米融合机器，将其货物直接输送到细胞的细胞质。

As we transition to the CCR Nanobiology Program, we are planning and designing experiments on the lipid-based nanocapsules and nano fusion machines. We believe that our knowledge and skills in elucidating mechanisms of viral entry will be of benefit to find new ways to deliver anti-cancer drugs. The anticipated projects include design and study of multifunctional liposomes bearing drugs (e.g. toxic or anti-inflammatory substances), conjugated with a disease-specific targeting agent (e.g. antibodies), and labeled with imaging agents. We plan to use external sources of energy (X-rays, light, microwave, ultrasound) for controlled disruption of liposomes at the optimal time and within a limited volume. The liposomes will be protected by polymers or polymerized lipids and modified to allow controlled disruption. We plan to exploit a new class of fusion-associated small transmembrane (FAST) proteins to build nano fusion machines that will directly deliver their cargo to the cells' cytoplasm.