DNA Microarray Shared Resource

DNA微阵列共享资源(DMSR)的目标是促进前沿技术的应用 癌症中心成员的微阵列技术和分析技术。提供的服务包括 生产目录和定制斑点微阵列，支持使用多种格式的 斯坦福大学和商业微阵列，协助实验设计，阵列数据归档和 生物信息学工具，用于微阵列数据的注释、分析、可视化和发布。 DMSR结合了斯坦福功能基因组学设施的资源，该设施开发了新的 基因组学技术，以及斯坦福微阵列数据库，这是最大和最广泛的 使用支持微阵列研究的公共数据库。DMSR为癌症中心提供附加值 通过减少与微阵列实验相关的财务障碍并为成员提供 设计、执行、分析和出版所需的必要培训和专业知识 基因芯片实验。我们高度整合的基因组学和信息学小组定期进行互动 与癌症中心成员合作，确保产生的微阵列数据高质量和安全 存档以供分析和解释以及出版和长期查阅。当前的成功 这一共享资源的重要性体现在得到支持的高影响力出版物上。AS 截至2005年7月，由共享资源支持的59项癌症研究已经发表，其中14项是 2005年出版。在2005财政年度，微阵列和数据服务的使用总数为15,937项，其中 51%是由癌症中心成员提供的，这些成员来自十分之九的研究项目。这方面的未来计划 共享资源包括将基因组学工作扩展到所有形式的基于微阵列的分析 包括抗体阵列、蛋白质阵列和反相细胞裂解物阵列。此外，我们的 生物信息学能力将通过纳入新的方法而显著扩展 与癌症相关的信息的质量评估、数据分析和数据注释。

The goal of the DNA Microarray Shared Resource (DMSR) is to facilitate the application of cutting-edge microarray technology and analysis techniques by Cancer Center members. Services provided include the production of catalog and custom spotted microarrays, support of the use of multiple formats of Stanford and commercial microarrays, assistance with experimental design, archiving of array data and bioinformatics tools for the annotation, analysis, visualization and publication of microarray data. DMSR combines the resources of the Stanford Functional Genomics Facility, which develops new technology for genomics, and the Stanford Microarray Database, which is the largest and mostly widely used public database supporting microarray research. DMSR provides added value to Cancer Center members by decreasing the financial barriers associated with microarray experiments and providing the necessary training and expertise needed for the design, execution, analysis and publication of microarray experiments. Our strongly integrated genomics and informatics groups routinely interact with Cancer Center members to ensure that the microarray data generated are high quality and securely archived for analysis and interpretation as well as publication and long-term access. The current success of this Shared Resource is demonstrated by the high-impact publications that have been supported. As of July 2005, 59 cancer studies supported by the Shared Resource have been published, 14 of which were published in 2005. In fiscal year 2005, use of the microarray and data services totaled 15,937, of which 51% are by Cancer Center members from nine out of ten Research Programs. Future plans for this Shared Resource include expansion of the genomics efforts into all forms of microarray-based assays including antibody arrays, protein arrays, and reverse-phase cell lysate arrays. In addition, our bioinformatics capabilities will be significantly expanded by the incorporation of novel approaches for quality assessment, data analysis and annotation of data with cancer-related information.