PROG 7- Cancer Immunology and Immunotherapy

癌症免疫学和免疫治疗项目的重点是了解相互作用 宿主免疫系统与肿瘤之间的关系以及临床上的发现和发展 有效的抗肿瘤免疫疗法。该项目由高度互动的教职员工组成 他们的学术兴趣是分子和细胞免疫生物学，医学，外科和 斯坦福大学医学院的病理学。每个教职员工都有自己的 由研究人员发起的拨款支持的研究计划。此外，每个教职员工都是 积极教授研究生和医学生，以及培训博士后研究员和住院医生。 我们正在采取三种相辅相成的方法来实现我们方案的三个目标。 操纵肿瘤患者的免疫系统细胞，目的是利用 该系统具有精巧的特异性，可以实现肿瘤的根除，而没有明显的毒性。 ？开发新的、更精确的方法来测量和监测对 荷瘤宿主中的肿瘤。 ？了解T细胞和其他细胞所使用的生化和信号通路。 免疫效应细胞对肿瘤的反应和细胞的运输模式。 了解和操纵对肿瘤，特别是实体肿瘤的免疫反应是主要的 统一本研究计划参与者的研究兴趣，以及我们实现 目标高度依赖于来自其他计划的基础和翻译调查人员 癌症中心和共享资源。

The Program in Cancer Immunology and Immunotherapy is focused on understanding the interactions between the host immune system and tumors, and on the discovery and development of clinically effective anti-tumor immunotherapy. The Program is comprised of highly interactive faculty members whose academic interests are in molecular and cellular immunobiology, medicine, surgery and pathology in the Stanford University School of Medicine. Each faculty member has his or her own research program that is supported by investigator initiated grants. In addition, each faculty member is active in teaching graduate and medical students, as well as training postdoctoral fellows and residents. Three complementary approaches are being taken to achieve the three goals of our program. ¿ To manipulate cells of the immune system in patients with tumors with the goal of utilizing the exquisite specificity of this system to achieve tumor eradication without significant toxicity. ¿ To develop new and more precise ways of measuring and monitoring the immune response to tumors in tumor-bearing hosts. ¿ To develop an understanding of the biochemical and signaling pathways used by T cells and other immune effector cells in both their response to tumors and their cellular trafficking patterns. Understanding and manipulating the immune response to tumors, particularly solid tumors, is the major unifying research interest of the participants in this Research Program, and our ability to achieve our objectives is highly dependent on both basic and translational investigators from the other Programs in the Cancer Center and on the Shared Resources.