CORE--ANALYTICAL LABORATORY

该设施为与中心研究人员的研究兴趣相关的分子提供经济高效和准确的化学分析。它也是与分析化学中分析物的量化和策略相关的咨询的基础。提供先进方法的服务和专业知识，包括最先进的技术，特别是液-质联用(LC/MS)和气相色谱-质谱联用(GC/MS)。此外，还为研究人员提供了临床标志物的常规分析和测定。在夏威夷州没有其他实验室可以提供其中的许多服务。通过参加内部和外部质量保证计划，包括参加由国家标准与技术研究所组织的循环测试，持续监测高质量的服务。这一共享资源的提供提供了最先进的服务，改善了对调查人员的反馈，促进了跨学科合作，并为CRCH调查人员提供了更具成本效益的服务。预计在可预见的未来，目前的满负荷使用将继续下去。需要资源服务的新资助项目的数量将超过来年终止的项目数量。本周期通过CCSG支助赠款获得的设备极大地增强了这一资源的潜力。自成立以来，这一设施显示出显著的增长，其对中心研究的价值体现在它的广泛使用上，目前为来自所有三个项目的11名CRCH调查人员提供服务，过去四年的服务产出增加了两倍多，并利用共享资源在01-04财年出版了32篇同行评议的手稿。

This facility provides cost-effective and accurate chemical analyses for molecules relevant to research interests of Center investigators. It is also a base for consultation related to the quantisation of analytes and strategies in analytical chemistry. Services and expertise in advanced methods are available including state-of-the-art techniques, particularly liquid chromatography mass spectrometry (LC/MS) and gas chromatography mass spectrometry (GC/MS). In addition routine analyses and determinations of clinical markers are offered to investigators. No other laboratories are available to provide many of these services in the State of Hawaii. The high quality of services is continually monitored by taking part in internal and external quality assurance programs including the participation in round robin tests organized by the National Institute of Standards and Technology. The availability of this Shared Resource provides state-of-the-art services, improves feedback to the investigators, stimulates inter-disciplinary collaborations, and provides more cost-effective service to CRCH investigators. The current use at full capacity is anticipated to continue for the foreseeable future. Newly funded projects requiring services of the resource will outnumber projects terminating in the coming year. Equipment obtained through the CCSG support grant in the current cycle has greatly enhanced the potential of this resource. This facility has shown remarkable growth since its inception and its value to Center research is reflected in its broad usage, currently servicing eleven CRCH investigators from all three Programs, more than a twofold increase in service output the past four years, and the publication of 32 peer reviewed manuscripts in FY01-FY04 utilizing the shared resource.