BEHAVIORAL AND REINFORCING EFFECTS OF ALPRAZOLAM IN MONKEYS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。苯二氮卓类（BZ）作为镇静剂和抗焦虑剂在临床上是有效的;然而，不必要的副作用会限制它们的有用性。我们研究了恒河猴中常规BZ阿普唑仑的镇静作用和滥用相关作用之间的关系。在两组猴中确定了产生镇静和静脉自我给药行为体征所需的阿普唑仑最低有效剂量（MED）。阿普唑仑诱导了镇静作用并维持了自我给药行为;然而，MED分析表明，镇静作用发生在高于维持自我给药所需剂量的剂量下。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Benzodiazepines (BZs) are clinically effective as sedatives and anxiolytics; however, unwanted side effects can limit their usefulness. We examined the relationship among the sedative and abuse-related effects of the conventional BZ alprazolam in rhesus monkeys. The minimally effective doses (MEDs) of alprazolam required to engender behavioral signs of sedation and i.v. self-administration were determined in two groups of monkeys. Alprazolam induced sedative effects and maintained self-administration behavior; however, analyses of MEDs indicated sedation occurred at doses higher than the doses required to maintain self-administration.