SUBJECTIVE/REINFORCING EFFECTS OF HEROIN-BENZODIAZEPINE COMBINATIONS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。大量的临床数据表明，阿片类成瘾者经常滥用苯二氮卓类药物（BZ）与海洛因或美沙酮维持治疗。最近的研究表明，这种形式的多种药物滥用反映了BZ增强了海洛因和其他类阿片激动剂的滥用相关作用。在恒河猴训练区分海洛因从盐水，传统的非选择性BZ三唑仑没有共享的歧视性刺激效应与海洛因。此外，当两种药物联合给药时，两种药物之间没有相互作用，其剂量可将反应率降低到控制率的50%以下。在恒河猴训练下的静脉注射药物的渐进比例时间表，海洛因和传统的BZ劳拉西泮保持剂量依赖性和可靠的自我管理。初步研究表明，将相对低剂量的海洛因与低剂量的劳拉西泮结合使用，与单独使用任何一种药物相比，自我给药的情况显著增加。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. An extensive body of clinical data indicates that opioid addicts regularly abuse benzodiazepines (BZs) in conjunction with heroin or methadone maintenance therapy. Recent research suggests that this form of polydrug abuse reflects an enhancement of the abuse-related effects of heroin and other opioid agonists by BZs. In rhesus monkeys trained to discriminate heroin from saline, the conventional non-selective BZ triazolam did not share discriminative stimulus effects with heroin. Furthermore, there was no interaction between the two drugs when administered in combination up to doses that reduced rates of responding below 50 per cent of control rates. In rhesus monkeys trained under a progressive ratio schedule of i.v. drug injection, both heroin and the conventional BZ lorazepam maintained dose-dependent and reliable self-administration. Preliminary studies indicate that combining a relatively low dose of heroin with a low dose of lorazepam resulted in a significant increase in self-administration compared to either drug individually.