A NONHUMAN MODEL OF OBSTRUCTIVE RENAL DYSPLASIA

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。目的：这些研究的目的是在非人类灵长类动物模型中调查梗阻性肾脏疾病的产前发病机制，该模型与在人类中观察到的疾病相似。这一模型的一个重要特征是重现了正常肾小球的发育和结构，这与足细胞的显著凋亡有关，早在血管形成前的S形状的肾单位就很明显。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: The objective of these studies is to investigate the prenatal pathogenesis of obstructive renal disease in a nonhuman primate model that parallels the disease observed in humans. An important feature of this model is the recapitulation of normal glomerular development and architecture, which is associated with significant podocyte apoptosis and is evident as early as the pre-vascularized S-shaped nephron.