COGNITIVE FUNCTION IN THE AGED MONKEY

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。该项目的总体目标是确定正常的非病理性衰老对记忆组成过程的影响，并评估这些变化与恒河猴卵巢激素损伤标志物的关系。对年轻和老年受试者进行了一系列经过充分研究的标准化神经心理学任务以及新开发的旨在提供认知老化敏感窗口的程序的测试。在整个项目中定期测定所有雌性猴的尿激素谱，以将这些参数与年龄相关记忆衰退状态的个体差异相关联。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall aims of the project are to define the effects of normal, non-pathological aging on the component processes of memory, and to evaluate these changes in relation to markers of ovarian hormone impairment in rhesus monkeys. Groups of young and aged subjects are tested across a battery of well-studied, standardized neuropsychological task as well as newly developed procedures designed to provide a sensitive window on cognitive aging. Urinary hormone profiles are determined for all female monkeys periodically throughout the project in order to relate these parameters to individual differences in the status of age-related memory decline.