BARTONELLA MODEL FOR AN AIDS OPPORTUNISTIC PATHOGEN

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。目的：利用SIV/猕猴模型系统来确定巴尔通体感染在SIV感染的免疫受损猕猴中的发病机制，并评估SIV/猕猴系统作为BA的潜在模型。SIV感染的动物，在免疫缺陷的不同阶段，将皮内接种B。henselae，B.杆状菌或B. quintana微生物，并监测菌血症的发作、持续时间、免疫应答和临床结果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: Utilize the SIV/macaque model system to determine the pathogenesis of Bartonella infection in SIV-infected, immunocompromised macaques, and evaluate the SIV/macaque system as a potential model for BA. SIV-infected animals, at various stages of immunodeficiency, will be inoculated intradermally with B. henselae, B. bacilliformis, or B. quintana organisms, and monitored for onset, duration, immune response, and clinical outcome of bacteremia.