BARTONELLA MODEL FOR AN AIDS OPPORTUNISTIC INFECTION

桌子下面的抽象。 使用Word Count cmd 利用菜单计数显著巴尔通体病，由 感染汉赛巴尔通体或B菌。金塔纳群岛 作为一种重要的机会性感染， 艾滋病 汉赛巴尔通体是猫抓病的病原体 疾病，而B.金塔纳是“战壕热”的代理人， 免疫活性宿主的自限性感染。 巴尔通体 艾滋病患者或其他免疫受损宿主的感染， 然而，与严重威胁生命的 血管组织增殖影响多个器官系统; a 被称为杆菌性血管瘤病（BA）或杆菌性血管瘤病的病症 紫癜。 导致发展的发病机制 这些损伤是未知的。 目的利用SIV/猕猴 模型系统，以确定巴尔通体感染的发病机制， SIV感染，免疫功能低下的猕猴，并评估效用 SIV/猕猴系统作为BA的潜在模型。 siv感染 处于免疫缺陷不同阶段的动物将接种 巴尔通体属（Bartonella spp.） 并监测发作、持续时间、免疫 反应和菌血症的临床结果。 结果巴尔通体 已经在SIV感染的猕猴中建立了细菌学， 特异性免疫参数。 监测这些动物的 临床过程和长期后遗症的表征是 持续进行。 未来的方向额外的巴尔通体接种将 在SIV感染和未感染SIV的猕猴中进行， 发病机制的研究和进一步的模型开发。 关键词 巴尔通体、杆菌性血管瘤病、SIV、艾滋病、恒河猴 NIH RR 00169初步研究-研究完成-由NIH资助1998年12月1日 A143703

beneath the table to the abstract. Use the Word Count cmd under Utilites menu for counting Significance Bartonellosis, caused by infection with the bacteria Bartonella henselae or B. quintana, is emerging as an important opportunistic infection in patients with AIDS. Bartonella henselae is the etiologic agent of cat-scratch disease, while B. quintana is the agent of "trench fever", both self-limiting infections in immunocompetent hosts. Bartonella infection in AIDS patients, or other immune compromised hosts, however, has been associated with a severe life threatening proliferation of vascular tissue affecting multiple organ systems; a condition referred to as bacillary angiomatosis (BA) or bacillary peliosis. The pathogenetic mechanisms leading to the development of these lesions are unknown. Objectives To utilizing the SIV/macaque model system to determine the pathogenesis of Bartonella infection in SIV-infected, immunocompromised macaques, and to evaluate the utility of the SIV/macaque system as a potential model for BA. SIV-infected animals, at various stages of immunodeficiency, will be inoculated with Bartonella spp. and monitored for onset, duration, immune response, and clinical outcome of bacteremia. Results Bartonella bacteremias have been established in SIV-infected macaques having specific immunologic parameters. Monitoring of these animals for characterization of clinical course and long-term sequelae is on-going. Future Directions Additional Bartonella inoculations will be performed in SIV-infected and SIV-uninfected macaques to expand studies of pathogenesis and further model development. KEY WORDS Bartonella, bacillary angiomatosis, SIV, AIDS, rhesus macaque FUNDING NIH RR00169 Pilot Study - Study Complete - Funded by NIH 12/1/98 A143703