CHARACTERIZATION OF EPILEPSY IN THE PEDIGREED BABOONS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。在人类和动物中，癫痫有许多不同的分类。癫痫发作和癫痫的分类需要详细的临床病史和与发作间期脑电图（EEG）的相关性。在动物中，为了进一步表征癫痫发作类型，需要仔细观察癫痫发作和频率。据报道，在SFBR的纯种狒狒自发性癫痫发作超过15年。癫痫发作没有任何明显的神经病理、毒性或代谢异常，但癫痫发作的类型和频率没有很好的特征。癫痫发作的频率太低，不需要持续观察或监测。然而，不同类型的癫痫有不同的脑电图模式。这些脑电图的信息可以在清醒的癫痫患者身上获得和研究，在检查期间没有临床发作活动。此外，间歇性光刺激（光刺激）可在易感动物中诱发癫痫发作的临床表现。对癫痫狒狒的初步调查使用光刺激和脑电图记录的组合来表征癫痫的类型，已经证明了三种不同的癫痫类型。这些动物代表了一种独特的遗传性癫痫动物模型。从临床和遗传学的角度来看，它们将有助于研究人类癫痫和测试用于治疗癫痫的新药。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In humans and animals, there are many different classifications of epilepsy. The classification of seizures and epilepsy requires a detailed clinical history and correlation with interictal (between seizure) electroencephalography (EEG). In animals, to further characterize the seizure types, a careful observation of the seizures and the frequency is required. Spontaneous seizures have been reported in the pedigreed baboons at SFBR for over 15 years. The seizures have occurred in the absence of any overt neuropathologic, toxic or metabolic abnormalities, but the seizure types and frequency have not been well characterized. The seizures occur too infrequently to warrant continuous observation or monitoring. Different types of epilepsy, however, have distinctive EEG patterns. The information from these EEGs can be obtained and studied in an awake epileptic individual that is not having clinical seizure activity during the exam. Also intermittent light stimulation (photostimulation) can, in predisposed animals, induce clinical manifestations of epilepsy, seizures. A preliminary survey of the epileptic baboons using a combination of photostimulation and EEG recordings to characterize the type of epilepsy has demonstrated 3 distinct epileptic types. These animals represent a unique animal model for inherited epilepsy. From a clinical and genetic standpoint they will be useful to study epilepsy in humans and to test new drugs used to treat epilepsy.