NEUTRALIZING ANTIBODY INDUCTION IN BABOONS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。人类免疫缺陷病毒（HIV）在21多年前被确定为艾滋病的病原体，该病毒已造成约2300万人死亡，估计全世界已感染近4600万人。没有有效的疫苗可预防病毒的进一步传播。在这个提议中，我们想在狒狒模型中研究新的候选艾滋病疫苗的免疫原性，希望能确定一个合适的疫苗配方用于人体试验。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Human immunodeficiency virus (HIV) was identified as the causative agent of AIDS more than 21 years ago and the virus has killed approximately 23 million people and is estimated to have infected nearly 46 million people worldwide. No effective vaccine is available for prevention of further spread of the virus. In this proposal, we would like to study the immunogenicity of novel candidate AIDS vaccines in the baboon model to hopefully identify a suitable vaccine formulation for human trials.