LUMBAR ARTIFICIAL DISC WITH NEW POLYMER, MOTION CONSTRAINTS AND EMBEDDED ELECTRO

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。在未来几年内，用人工椎间盘置换退变的椎间盘将在美国变得司空见惯。人工椎间盘的设计是为了承受人类脊柱中的载荷，这一点人们知之甚少。这种实验性椎间盘设计有嵌入式电子设备，以帮助外科医生管理患者，使植入物成功长期存活。带有传感器的植入物将为外科医生和患者提供前所未有的数据，以实现这一目标。该椎间盘在机械上不同于临床试验中的任何球窝椎间盘。将在狒狒模型中研究其机械功能，以获得初步数据，从而设计外国人体试验。如果新器械的性能符合预期，则可能会为患者提供更好的生活质量，而需要再次手术的机会更少或时间更长。患者更有可能更快地回到体力劳动岗位，并了解他们的工作如何影响他们的假肢和脊柱。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The replacement of degenerated discs by prosthetic discs will become commonplace in the US over the next few years. Prosthetic discs are designed to withstand loads in the human spine that are poorly understood. This experimental disc is designed with embedded electronics to help the surgeon manage the patient for successful long-term survival of the implant. Implants with sensors will give unprecedented data o the surgeon and patient toward this goal. This disc is mechanically different than any of the ball and socket discs in clinical trials. Its mechanical function will be investigated in the baboon model to obtain preliminary data in order to design a foreign human trial. If the new device performs as expected, it offers the potential for better quality of life for the patient with less chance or longer time before re-operation is required. Patients are more likely to return to manual labor jobs more quickly and with knowledge of how their job affects their prosthesis and spine.