MR SPECTROSCOPY OF TUMORS & SURROUNDING TISSUE IN ABDOMEN OR PELVIS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。本研究的具体目的是利用质子MRS精确鉴定肾细胞癌（RCC）与正常肾组织相比存在的代谢物，以确定是否存在将RCC与良性肿瘤（如嗜酸细胞瘤和血管平滑肌脂肪瘤）和其它恶性病变（如淋巴瘤、移行细胞癌和转移瘤）区分开的特定代谢指纹;并确定MRS与肿瘤的组织学分级、分期、大小和转移潜能之间是否存在相关性，而与分期和分级无关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The specific aims of this study are to precisely identify the metabolites present in renal cell carcinoma (RCC) compared to normal renal tissue utilizing proton MRS, to determine if there is a specific metabolic fingerprint that differentiates RCC from benign tumors such as oncocytoma, and angiomyolipoma, and from other malignant lesions such as lymphoma, transitional cell carcinoma, and metastasis; and to determine if there is a correlation between the MRS and the histologic grade, stage, size of tumor and metastatic potential independent of stage and grade.