STRUCTURE & MECHANISM OF HYDROLYTIC ANTIBODIES

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。我们正在研究一个独特的催化抗体家族的结构和机制，以建立规则，从而允许产生更活跃的催化抗体。使用各种化学，生物化学和分子生物学技术，我们正在以结构指导的方式对催化抗体进行工程改进。我们的目标是监测这些催化改进工程所涉及的结构-功能关系。339S

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are studying the structure and mechanisms of a unique family of catalytic antibodies in an effort to establish rules that will permit more active catalytic antibodies to be generated. Using a variety of chemical, biochemical and molecular biology techniques, we are engineering improvements into our catalytic antibodies in a structure-guided way. Our goal is to monitor the structure-function relationships involved in engineering these catalytic improvements. 339S