NOVELTY DIFFERENTIALLY MODULATES MEDIAL TEMP LOBE& BASAL GANGLIA MEMORY SYS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。越来越多的证据表明，内侧颞叶（MTL）支持单次快速连接学习，而基底神经节（BG）支持刺激-反应关联的增量学习。最近的数据提出了这些神经系统在学习过程中可能相互作用的可能性，其他数据表明这两个系统在处理新颖性方面都起着重要作用。综上所述，这些发现提出了一些重要的问题，即新颖性如何调节不同形式的记忆，以及它们之间的相互作用。在这项研究中，我们使用功能性MRI检查了新颖性对联想学习和迁移过程中MTL和BG动态的影响。在这个两阶段的学习任务中，受试者首先进行同步的、基于反馈的强迫选择辨别，在那里他们学会了将面孔和场景联系起来。这个学习阶段之后是一个转移阶段，在这个阶段，研究对象被要求将以前学到的知识转移到新的环境中。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Extensive converging evidence suggests that the medial temporal lobe (MTL) supports rapid conjunctive learning from single episodes, while the basal ganglia (BG) support incremental learning of stimulus-response associations. Recent data have raised the possibility that these neural systems may interact during learning, with other data suggesting that both systems play an important role in processing novelty. Taken together, these findings raise important questions regarding how novelty modulates different forms of memory, and the interaction between them. In this study, we used functional MRI to examine the impact of novelty on MTL and BG dynamics during associative learning and transfer. In this two-phase learning task, subjects first engaged in a concurrent, feedback-based forced-choice discrimination, where they learned to associate faces and scenes. This learning phase was followed by a transfer phase, where subjects were probed to transfer previously learned knowledge to a new context.